FELINTO, MARIA C.F.C.CAMILO, RUTH L.DIEGUES, T.G.2014-11-172014-11-182015-04-022014-11-172014-11-182015-04-02FELINTO, MARIA C.F.C.; CAMILO, RUTH L.; DIEGUES, T.G. Magnetic nanoparticles and their application in biomedicine. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 8th/ MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 15th, Sept. 30 - Oct. 5, 2007, Santos, SP. <b>Proceedings...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/15715.http://repositorio.ipen.br/handle/123456789/15715The magnetic nanoparticles offer some attractive possibilities in biomedicine for the following reasons: First, they have controllable sizes ranging from a few nanometers up to tens of nanometers, which places them at dimensions that are smaller than or comparable to those of a cell (10– –450 nm) or a protein (5–50 nm). Second, the nanoparticles are magnetic, which means that they obey Coulomb’s law, and can be manipulated by an external magnetic field gradient. This possibility, combined with the intrinsic penetrability of magnetic fields into human tissue, opens up many applications involving the transport and/or immobilization of magnetic nanoparticles, or of magnetically tagged biological entities. Third, the magnetic nanoparticles can be made to resonantly respond to a time-varying magnetic field, with advantageous results related to the transfer of energy from the exciting field to the nanoparticle. In this paper, we will address the underlying chemical and physics of the biomedical applications of magnetic nanoparticles including radioisotope delivery and a magnetic radiolabeled fluid. We will consider four particular applications: magnetic separation for radio labeled proteins, drug radiolabeled delivery, hyperthermia treatments, and magnetic resonance imaging (MRI) contrast enhancement. There will be included some results obtained in our laboratory in the obtention of these magnetic nanoparticles.openAccessdrugshyperthermialabelled compoundsmagnetic fieldsnanostructuresnmr imagingparticlesproteinstherapeutic usesvirusesTexto completo de eventohttps://orcid.org/0000-0001-7028-0878