NEGRON, ANA C.V.ROGERO, SIZUECRUZ, AUREA S.SILVA, DENISE O.2014-11-172014-11-182015-04-022014-11-172014-11-182015-04-02NEGRON, ANA C.V.; ROGERO, SIZUE; CRUZ, AUREA S.; SILVA, DENISE O. Effects of binding metronidazole to a copper acetate compound on radiosensitizer properties. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st, September 27 - October 2, 2009, Rio de Janeiro, RJ. <b>Proceedings...</b> DisponÃvel em: http://repositorio.ipen.br/handle/123456789/16582.http://repositorio.ipen.br/handle/123456789/16582Copper compounds exhibit interesting biological properties. Nitroimidazoles show radiosensitizer properties for radiotherapy tumor treatment. In the present work, the effect of binding metronidazole (1-(2-hidroxyethyl)-2- methyl-5-nitroimidazole = MTZ) to copper-acetate on the radiosensitizer properties has been investigated. A compound of copper-acetate-MTZ was prepared and characterized. The experiments were carried out by gamma-irradiation of Hep2 (human larynx cancer) cells under hypoxic conditions. The radiation doses for 50% cell survival in the presence of radiosensitizer were about 8.2 Gy for CuAcMTZ or free MTZ. The effect of binding metronidazole to copper acetate on radiosensitizer properties is mainly related to the radiosensitizer process which involves two events for CuAcMTZ in contrast to one event observed for the MTZ free drug.openAccesscell culturescobalt 60copper compoundscopperculture mediaexperimental datagamma radiationlarynxmetronidazoleradiation dosesradioprotective substancesradiosensitivity effectstumor cellsEffects of binding metronidazole to a copper acetate compound on radiosensitizer propertiesTexto completo de eventohttps://orcid.org/0000-0003-3396-6277