KATTI, K.V.KHOOBCHANDANI, M.THIPE, V.C.AL-YASIRI, A.Y.KATTI, K.K.LOYALKA, S.K.SAKR, T.M.LUGAO, A.B.2019-01-312019-01-312018KATTI, K.V.; KHOOBCHANDANI, M.; THIPE, V.C.; AL-YASIRI, A.Y.; KATTI, K.K.; LOYALKA, S.K.; SAKR, T.M.; LUGAO, A.B. Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles. <b>Journal of Radioanalytical and Nuclear Chemistry</b>, v. 318, n. 3, p. 1737-1747, 2018. DOI: <a href="https://dx.doi.org/10.1007/s10967-018-6320-4">10.1007/s10967-018-6320-4</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/29425.0236-5731http://repositorio.ipen.br/handle/123456789/29425We report herein an innovative approach to prostate tumor therapy using tumor specific radioactive gold nanoparticles (198Au) functionalized with Mangiferin (MGF). Production and full characterization of MGF-198AuNPs are described. In vivo therapeutic efficacy of MGF-198AuNPs, through intratumoral delivery, in SCID mice bearing prostate tumor xenografts are described. Singular doses of the nano-radiopharmaceutical (MGF-198AuNPs) resulted in over 85% reduction of tumor volume as compared to untreated control groups. The excellent anti-tumor efficacy of MGF-198AuNPs are attributed to the retention of over 90% of the injected dose within tumors for long periods of time. The retention of MGF-198AuNPs is also rationalized in terms of the higher tumor metabolism of glucose which is present in the xanthanoid functionality of MGF. Limited/no lymphatic drainage of MGF-198AuNPs to various non-target organs is an attractive feature presenting realistic scope for the clinical translation of MGF-198AuNPs in for treating prostate cancers in human patients. The comparative analysis of MGF-198AuNPs with other radioactive gold nanoparticles, functionalized either with epigallocatechin gallate or the Gum Arabic, has revealed significantly superior tumoricidal characteristics of MGF-198AuNPs, thus corroborating the importance of the tumor-avid glucose motif of MGF. Oncological implications of MGF-198AuNPs as a new therapeutic agent for treating prostate and various solid tumors are presented.1737-1747openAccessneoplasmsprostatenuclear medicinegoldnanoparticlestherapynanotechnologyradiation effectsbrachytherapyArtigo de periódico331810.1007/s10967-018-6320-4aguardandohttps://orcid.org/0000-0002-1737-319129.2345.29