NASCIMENTO, M.H.M.FRANCO, M.K.K.D.YOKAICHYIA, F.PAULA, E. deLOMBELLO, C.B.ARAUJO, D.R. de2018-07-192018-07-192018NASCIMENTO, M.H.M.; FRANCO, M.K.K.D.; YOKAICHYIA, F.; PAULA, E. de; LOMBELLO, C.B.; ARAUJO, D.R. de. Hyaluronic acid in Pluronic F-127/F-108 hydrogels for postoperative pain in arthroplasties: Influence on physico-chemical properties and structural requirements for sustained drug-release. <b>International Journal of Biological Macromolecules</b>, v. 111, p. 1245-1254, 2018. DOI: <a href="https://dx.doi.org/10.1016/j.ijbiomac.2018.01.064">10.1016/j.ijbiomac.2018.01.064</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28976.0141-8130http://repositorio.ipen.br/handle/123456789/28976In this study,we reported the hyaluronic acid (HA) on supramolecular structure of Pluronic F-127 (PLF-127) and/ or Pluronic F-108 (PLF-127) hydrogels, as well as their effects on release mechanisms, looking forward their application as lidocaine (LDC) drug-delivery systems in arthroplastic surgeries.We have studied the HA-micelle interaction using Dynamic Light Scattering (DLS), themicellization and sol-gel transition processes by Differential Scanning Calorimetry (DSC) and Rheology., of PL-based hydrogels and. The presence of HA provided the formation of larger micellar dimensions from ~26.0 to 42.4 nm. The incorporation of HA did not change the micellization temperatures and stabilized hydrogels rheological properties (G′ N G″), showing no interference on PLthermoreversible properties. Small-Angle-X-ray Scattering (SAXS) patterns revealed that HA incorporation effects were pronounced for PLF-127 and PLF-108 systems, showing transitions from lamellar to hexagonal phase organization (HA-PLF-127) and structural changes from cubic to gyroid and/or cubic to lamellar. The HA insertion effects were also observed on drug release profiles, since lower LDC release constants (Krel = 0.24–0.41 mM·h−1) were observed for HA-PLF-127, that presented a hexagonal phase organization. Furthermore, the HA-PL systems presented reduced in vitro cytotoxic effects, pointed out their tendency to selfassembly and possible application as drug delivery systems.1245-1254openAccesshyaluronic acidpluronicshydrogelsanestheticscalorimetrytoxicitymicellar systemssmall angle scatteringdrug deliveryArtigo de periódico11110.1016/j.ijbiomac.2018.01.06487.3976.00