SAMANTA ETEL TREIGER BORBOREMA
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Artigo IPEN-doc 25063 Pharmacokinetic of meglumine antimoniate encapsulated in phosphatidylserine-liposomes in mice model2018 - BORBOREMA, SAMANTA E.T.; OSSO JUNIOR, JOAO A.; TEMPONE, ANDRE G.; ANDRADE JUNIOR, HEITOR F. de; NASCIMENTO, NANCI doVisceral leishmaniasis (VL) is a fatal parasitic disease caused by the protozoan Leishmania spp. Meglumine antimoniate (MA) is the main treatment and has demonstrated a promising efficacy in a VL-model when encapsulated into negatively charged liposomes. Considering the current concept for the evaluation of pharmacokinetic parameters at early phases of drug discovery, we developed a formulation of MA-encapsulated into phosphatidylserine liposomes (MA-LP) and analyzed the in vitro antileishmanial activity, physicochemical properties, and pharmacokinetic profile in a mice model. The liposomal formulation had an internal mean diameter of 114 nm and a high stability in plasma. MA-LP was 23-fold more in vitro effective against Leishmania infantum-infected macrophages than the free drug, with a selectivity index higher than 220. The pharmacokinetic studies demonstrated that the liposomes increased the uptake of the drug by the liver and spleen and promoted sustained levels. MA-LP was first eliminated through renal excretion, followed by biliary excretion. In the blood, MA-LP followed a biexponential open model. This work emphasizes the importance of liposomes as potential drug delivery systems for visceral leishmaniasis.Artigo IPEN-doc 11423 Synthesis and antieshmanial activities of novel 3 substituted quinolines2005 - TEMPONE, ANDRE G.; SILVA, ANA C.M.P.; BRANDT, CARLOS A.; MARTINEZ, FERNANDA S.; BORBOREMA, SAMANTA E.T.; SILVEIRA, MARIA A.B.; ANDRADE JUNIOR, HEITOR F.Artigo IPEN-doc 17564 Uptake and antileishmanial activity of meglumine antimoniate-containing liposomes in Leishmania (leishmania) major-infected macrophages2011 - BORBOREMA, SAMANTA E.T.; SCHWENDENER, RETO A.; OSSO JUNIOR, JOAO A.; ANDRADE JUNIOR, HEITOR F. de; NASCIMENTO, NANCI