SAMANTA ETEL TREIGER BORBOREMA
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Artigo IPEN-doc 25063 Pharmacokinetic of meglumine antimoniate encapsulated in phosphatidylserine-liposomes in mice model2018 - BORBOREMA, SAMANTA E.T.; OSSO JUNIOR, JOAO A.; TEMPONE, ANDRE G.; ANDRADE JUNIOR, HEITOR F. de; NASCIMENTO, NANCI doVisceral leishmaniasis (VL) is a fatal parasitic disease caused by the protozoan Leishmania spp. Meglumine antimoniate (MA) is the main treatment and has demonstrated a promising efficacy in a VL-model when encapsulated into negatively charged liposomes. Considering the current concept for the evaluation of pharmacokinetic parameters at early phases of drug discovery, we developed a formulation of MA-encapsulated into phosphatidylserine liposomes (MA-LP) and analyzed the in vitro antileishmanial activity, physicochemical properties, and pharmacokinetic profile in a mice model. The liposomal formulation had an internal mean diameter of 114 nm and a high stability in plasma. MA-LP was 23-fold more in vitro effective against Leishmania infantum-infected macrophages than the free drug, with a selectivity index higher than 220. The pharmacokinetic studies demonstrated that the liposomes increased the uptake of the drug by the liver and spleen and promoted sustained levels. MA-LP was first eliminated through renal excretion, followed by biliary excretion. In the blood, MA-LP followed a biexponential open model. This work emphasizes the importance of liposomes as potential drug delivery systems for visceral leishmaniasis.Artigo IPEN-doc 10604 Production of neutron-irradiated meglumine antimoniate and its biodistribution in healthy and Leishmania (L.) Chagasi infected mice2005 - BORBOREMA, S.E.T.; ANDRADE JUNIOR, H.F.; OLIVEIRA, A.; MURAMOTO, E.; OSSO JUNIOR, J.A.; NASCIMENTO, N.Artigo IPEN-doc 15116 Tissue distribution of radiolabeled phosphatidylserine containing liposome in mice2009 - BORBOREMA, SAMANTA E.T.; ANDRADE JUNIOR, HEITOR F.; OSSO JUNIOR, JOAO A.; NASCIMENTO, NANCIArtigo IPEN-doc 11941 Pharmacokinetic of antimony in mice with cutaneous leishmaniasis2007 - BORBOREMA, SAMANTA E.T.; ANDRADE JUNIOR, HEITOR F. de; OSSO JUNIOR, JOAO A.; NASCIMENTO, NANCI doDissertação IPEN-doc 11100 Biodistribuição do antimoniato de meglumina em animais sadios e infectados com Leishmania (L.) chagasi2005 - BORBOREMA, SAMANTA E.T.Resumo IPEN-doc 11815 Pharmacokinetic and tissue distribution of neutron irradiated pentavalent antimonials as anti-leishmanial drugs2006 - BORBOREMA, SAMANTA E.T.; ANDRADE JUNIOR, HEITOR F. de; OSSO JUNIOR, JOAO A.; NASCIMENTO, NANCI