RITA DE CASSIA MUTARELLI
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Tese IPEN-doc 27514 Tendência de mercado de radiofármacos do IPEN: uma abordagem de Dinâmica de Sistemas2020 - MUTARELLI, RITA de C.O Instituto de Pesquisas Energéticas e Nucleares (IPEN) é responsável por 95% dos radiofármacos utilizados em clínicas e hospitais. Além disso, o IPEN realiza aproximadamente 1,5 milhões de procedimentos de medicina nuclear por ano. O não atendimento dessa demanda trará problemas de saúde para a população. A gestão sustentável e de longo prazo desse mercado requer um monitoramento ativo entre a oferta e a demanda. O objetivo deste estudo é analisar o impacto da demanda do Tecnécio-99m (99mTc) produzido no IPEN, que é responsável por 80% dos procedimentos Medicina Nuclear com este radiofármaco, para um horizonte de tempo até 2035. A metodologia utilizada nesse estudo está baseada no paradigma de simulação da Dinâmica de Sistemas, combinado com dados empíricos obtidos das instituições e autoridades reguladoras. Esse estudo contribui para o gerenciamento futuro da produção do 99mTc. Embora existam estudos anteriores sobre esse assunto em outros países, esse trabalho destaca o papel que o IPEN desempenha nesse mercado e integra diversas variáveis em um processo de simulação de Dinâmica de Sistemas, para entender o mercado como um todo. Por esta razão, esse trabalho é original na área de radiofármacos. Os resultados das simulações realizadas com o modelo de Dinâmica de Sistemas desenvolvido nesse trabalho para os diferentes cenários propostos, mostram que o IPEN atenderá à demanda de 99mTc para 2035, desde que assuma os valores calculados para as seguintes variáveis: número de funcionários, infraestrutura e importação de matéria-prima.Artigo IPEN-doc 27149 IPEN radiopharmaceutical market trends2019 - MUTARELLI, RITA de C.; LIMA, ANA C. de S.; SANTOS, JOAQUIM R. dos; SABUNDJIAN, GAIANEThe Instituto de Pesquisas Energéticas e Nucleares (IPEN) is today responsible for providing radiopharmaceuticals for 80% of nuclear medicine procedures in Brazil. The aim of this study is to analyze the impact of different radiopharmaceutical demands on IPEN production. The methodology used in this study is based on the system dynamics simulation paradigm, combined with empirical data obtained from the institutions and regulatory authorities. The results from the simulations suggest that the IPEN's response to different demands depends on how it balances policies acting on the supply and demand for the resources. Sustainable and long-term management of this market requires active monitoring to support events caused by changes in demand. This study contributes to the systems dynamics and also to the radiopharmaceutical management literature, presenting an integrative model to evaluate the resilience of a specific market. Although there are previous studies on this subject in other countries, the present one focuses on the role that IPEN plays in this market and integrates several variables in a simulation process to understand the market as a whole. For this reason, this work is original in the area of radiopharmaceuticals.Artigo IPEN-doc 26225 Study of the demand-supply for radiopharmaceuticals in IPEN2019 - MUTARELLI, RITA de C.; LIMA, ANA C. de S.; SABUNDJIAN, GAIANERadiopharmaceuticals are unique medicinal formulations containing radioisotopes and are used in nuclear medicine for diagnosis and/or therapy for chronic diseases such as cancer, alzheimer and cardiac disorders. The increase in the incidence of these diseases in the Brazilian population and the trend of increasing demand for radiopharmaceuticals motivated the elaboration of this work from a system dynamics perspective. The aim of this paper is to present a System Dynamic Model for simulating the interaction between demand, capacity, workforce and production of radiopharmaceuticals produced by IPEN. The validity of this model is verified by running in Vensim PLE software using historical data. The model was based on the generic structure of commodity markets and main variables were considered to represent the market polices. The preliminary model presented was able to capture the expected behavior of the industry of radiopharmaceuticals. Two alternative scenarios were developed, one to analyze the impacts of investment in infrastructure of IPEN and the other to investigate the workforce investment. As result, the model performed well in representing the behavior of the market. In addition, scenario tests showed that investment in infrastructure and workforce investment have a significant impact in the dynamic of the system.