CELIA MARINA NAPOLITANO
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Artigo IPEN-doc 27369 Development of a shielding device for radiotherapy of breast cancer-bearing mice2020 - SILVA, C.R.; PEREIRA, S.T.; NAPOLITANO, C.M.; SOMESSARI, E.S.R.; RIBEIRO, M.S.Breast cancer is the fifth most common cause of death worldwide. Currently, one of the standard treatments for breast cancer is radiation therapy (RT). On the other hand, mouse models have been used in pre-clinical studies for breast cancer RT, requiring dedicated shielding to exposure the breast region. In this work, we considered the values of the lead attenuation coefficient and the material tenth reducing layer for 60Co gamma radiation and developed a lead shielding device for breast cancer-bearing mice to be exposed to localized breast RT. Five-kg of lead were heated to of 340ºC and inserted into an aluminum mold previously adjusted to the dimensions of the device. After solidification, the device was shaped into a cylinder with dimension of 14 x 15 x 7 cm (height x width x thickness, respectively). A round cut-out for breast exposure of 1 cm in diameter was made at 5 cm from the basis of the device. For shielding device validation, we performed calibrations to establish a dose of 10 Gy to the target volume. Fifteen CaSO4:Dy thermoluminescent dosimeters were distributed inside the conical tube to mimic the mouse position inside the shielding. The shielding device was placed at a fixed distance of 10 cm from the target for optimal exposure time. After irradiation, the dosimeters were read using a thermoluminescent reader. According to our results, we were able to develop a body-shielding device that assured the required dose for RT of breast cancer in mice.Artigo IPEN-doc 23141 Gamma radiation effects in packaging for sterilization of health products and their constituents paper and plastic film2018 - PORTO, KARINA M.B.G.; NAPOLITANO, CELIA M.; BORRELY, SUELI I.The integrity of materials containing packaging (natural or synthetic polymers) is essential to keep the aseptic condition of commercialized products (health care products, food and pharmaceuticals). The objective of this paper was to study gamma radiation effects (25 kGy, 40 kGy and 50 kGy) on the main properties of paper and multilayer films (polyester and polyethylene). Paper and multilayer films are components of packaging (pouches) for radiation sterilization containing medical equipment or products. Paper was the more radiation sensitive among the studied materials and radiation effects were more pronounced at brightness, pH, tearing resistance, bursting strength and tensile strength. Concerning plastic film, no pinholes were induced by radiation and the effects on the tensile strength were not significant. Although the seal strength packaging (pouches) decreased according to increasing dose, the sealing integrity was preserved.Resumo IPEN-doc 22213 Influência da temperatura na resposta de dosímetros de polimetilmetacrilato (PMMA)2005 - FERREIRA, DANILO C.; NAPOLITANO, CELIA M.; TOBIAS, CARMEN C.B.Resumo IPEN-doc 09226 High dose dosimetry on radiation processing at sup(60)Co gamma field2003 - NAPOLITANO, C.M.; CORREA, A.A.S.Artigo IPEN-doc 10679 Programa de qualificacao de um irradiador multiproposito de cobalto-60 tipo compacto2005 - RELA, P.R.; CALVO, W.A.P.; NAPOLITANO, C.M.; KODAMA, Y.; OMI, N.M.; COSTA, F.E.; FERREIRA, D.C.; ANDRADE e SILVA, L.G.Artigo IPEN-doc 16840 Research of the limit of the dosage of gamma irradiation supported by RFID tags2011 - SOARES, JOSE R.; RELA, PAULO R.; NAPOLITANO, CELIA M.Artigo IPEN-doc 11991 Implementation of good manufacturing practices (GMP) on human blood irradiation2007 - BOGHI, CLAUDIO; NAPOLITANO, CELIA M.; FERREIRA, DANILO C.; ZARATE, HERMAN S.; RELA, PAULO R.Artigo IPEN-doc 12088 Use of a PIN photodiode for dosimetric purposes in radiation processing2007 - FERREIRA, DANILO C.; CAMARGO, FABIO de; NAPOLITANO, CELIA M.; GONCALVES, JOSEMARY A.C.; KHOURI, HELEN J.; BUENO, CARMEN C.Artigo IPEN-doc 14929 Development of an irradiation system for a small size continuous run multipurpose gamma irradiator2009 - CALVO, WILSON A.P.; RELA, PAULO R.; NAPOLITANO, CELIA M.; KODAMA, YASKO; OMI, NELSON M.; COSTA, FABIO E. da; ANDRADE e SILVA, LEONARDO G. de