ANGELICA TAMIÃO ZAFALON
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Capítulo IPEN-doc 25620 Synthesis and characterization of PVP/CaCO3-Ag blend hydrogel by gamma irradiation2019 - ZAFALON, ANGELICA T.; JUVINO, VINICIUS dos S.; KOMATSU, LUIZ G.H.; PARRA, DUCLERC F.; LUGAO, ADEMAR; SAMUEL, TEMESGEN; RANGARI, VIJAYAChronic wounds are skin injuries with failed healing. They have become a public health problem that affects more than 2% of the population and the presence of bacteria resistances difficult of treatment. Pseudomonas aeruginosa is opportunist pathogens and the treatment is difficult and requires a long period of treatment. Hydrogels are structure polymeric tridimensional and biocompatible. They have been used as a controlled delivery system for treatment of topic infection. Studies have reported calcium carbonate and silver ion can improve the mechanical properties and biocide activity of hydrogel. Here in this study, hydrogels loaded CaCO3-Ag were prepared using poly (N-vinyl-2-pyrrolidone), poly (ethylene glycol), agar, calcium carbonate, silver nitrate followed gamma irradiation with 25 kGy dose. The gel fraction, behavior swelling and biocide action against P. aeruginosawas investigated. The degree of swelling of the hydrogel loaded CaCO3-Ag was 12% higher than the unloaded and exhibited antibacterial effects against P. aeruginosa and biofilm.Capítulo IPEN-doc 24657 Synthesis of polymeric hydrogel loaded with antibiotic drug for wound healing applications2018 - ZAFALON, ANGELICA T.; SANTOS, VINICIUS J. dos; ESPOSITO, FERNANDA; LINCOPAN, NILTON; RANGARI, VIJAYA; LUGAO, ADEMAR B.; PARRA, DUCLERC F.Polymeric hydrogels are natural or synthetic systems, which have gained interest due to their high biocompatibility with soft tissues. These types of hydrogels have been used for wound dressing as a drug delivery system. Here in this study the polymeric hydrogels based wound healing systems were prepared using poly (N-vinyl-2-pyrrolidone) (PVP), poly (ethylene glycol) (PEG), agar and neomycin drug followed by gamma irradiation to promote crosslinking and sterilization. The influence of irradiation process with 25 kGy dose was investigated. The gel fraction and maximum swelling were estimated using physicochemical methods and found about 95% gel fraction and 1100% swelling after 8 h of immersion. Neomycin released from hydrogel was carried out by Liquid Chromatography-Mass Spectrometry method and the drug concentration remained constant for 48 h. Hydrogel/neomycin exhibited antibacterial effects against Staphylococcus aureus. With these results, it can be inferred that hydrogel/neomycin is a suitable candidate for wound dressing.Artigo IPEN-doc 21022 Gamma radiation use for hydrogels of poly(N-vinyl 2-pyrrolidone) containing nanoclay laponite2015 - SANTOS, VINICIUS J. dos; TAVARES, ANGELICA T.; LUGAO, ADEMAR B.; RANGARI, VIJAYA K.; PARRA, DUCLERC F.