ANGELICA TAMIÃO ZAFALON
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Artigo IPEN-doc 25734 Stability of the neomycin antibiotic in irradiated polymeric biomaterials2018 - ZAFALON, ANGELICA T.; SANTOS, VINICIUS J. dos; LUGAO, ADEMAR B.; RANGARI, VIJAYA; TEMESGEN, SAMUEL; PARRA, DUCLERC F.Hydrogels can be produced by gamma radiation at 25 kGy. Free radicals from water radiolysis are responsible by crosslinking of the polymer and chain scission. On the other hand, gamma radiation can lead degradation of pharmaceuticals. Neomycin loaded hydrogel was prepared and the stabity of neomycin was evaluaded. Excipents were used to measure radioprotector potencial each one. HPLC-MS/MS method and thermal analysis were used to analysis effect of gamma irradiation in neomycin stability. PEG was a excipients in hydrogel formulation and showed to be a radioprotector. Neomycin was stable under gamma radiation when loaded in hydrogel.Tese IPEN-doc 25615 Synthesis and characterization of hydrogels loaded neomycin for infection topic treatment and veterinary use2018 - ZAFALON, ANGELICA T.Hydrogels are natural or synthetic polymer systems that have been vastly applied in the pharmaceutical industry due to their high soft tissue biocompatibility. These hydrogels have been used in dressings as a controlled drug release system. In this study, hydrogels were prepared using poly (N-vinyl-2-pyrrolidone) (PVP), poly (ethylene glycol) (PEG), agar and neomycin followed by gamma irradiation to promote crosslinking and sterilization. The influence of the irradiation process at 25 kGy dose was investigated. The gel fraction and maximum swelling were estimated using physicochemical methods and found about 95% gel fraction and 1100% swelling after 8 hours of immersion. Neomycin released from the hydrogel was measured by the Liquid Chromatography-Mass Spectrometry method and the drug concentration remained constant for 48 hours. Hydrogel / neomycin exhibited antibacterial effect against bacteria and biofilm of Pseudomonas aeruginosa and Staphylococcus aureus. The hydrogel was used in the treatment of pododermatitis in penguins healing process without signs of contamination. With these results, it can be inferred that the hydrogel / neomycin is a suitable candidate for wound dressings.Capítulo IPEN-doc 24657 Synthesis of polymeric hydrogel loaded with antibiotic drug for wound healing applications2018 - ZAFALON, ANGELICA T.; SANTOS, VINICIUS J. dos; ESPOSITO, FERNANDA; LINCOPAN, NILTON; RANGARI, VIJAYA; LUGAO, ADEMAR B.; PARRA, DUCLERC F.Polymeric hydrogels are natural or synthetic systems, which have gained interest due to their high biocompatibility with soft tissues. These types of hydrogels have been used for wound dressing as a drug delivery system. Here in this study the polymeric hydrogels based wound healing systems were prepared using poly (N-vinyl-2-pyrrolidone) (PVP), poly (ethylene glycol) (PEG), agar and neomycin drug followed by gamma irradiation to promote crosslinking and sterilization. The influence of irradiation process with 25 kGy dose was investigated. The gel fraction and maximum swelling were estimated using physicochemical methods and found about 95% gel fraction and 1100% swelling after 8 h of immersion. Neomycin released from hydrogel was carried out by Liquid Chromatography-Mass Spectrometry method and the drug concentration remained constant for 48 h. Hydrogel/neomycin exhibited antibacterial effects against Staphylococcus aureus. With these results, it can be inferred that hydrogel/neomycin is a suitable candidate for wound dressing.Artigo IPEN-doc 22888 Síntese e caracterização de hidrogéis contendo anti-microbiano neomicina2016 - SANTOS, V.J.; ZAFALON, A.T.; PARRA, D.F.Hidrogéis são biomateriais poliméricos vastamente utilizados para aplicações biomédicas como sistemas de liberação de fármaco. São materiais altamente hidrofílicos, com uma estrutura molecular reticulada e capacidade de absorver grandes quantidades de fluidos. Em geral hidrogéis são compostos por mais de um polímero sintético ou natural a fim modificar suas propriedades físico-químicas. Estes materiais podem ser produzidos através do uso de radiação ionizante, onde a radiação gama é uma das mais eficientes para a produção desses materiais. O objetivo deste trabalho foi sintetizar membranas de hidrogel a base de poli (N-vinil-2-pirrolidona), polietileno glicol e Agar, contendo antibiótico neomicina. As membranas de hidrogel foram produzidas por radiação gama de fontes de Co60 em doses de 25 kGy. Os hidrogéis foram caracterizados por meio da análise termogravimétrica (TGA) em que se identificou o antibiótico neomicina.