ANDRE LUIS LAPOLLI
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Resumo IPEN-doc 23307 Investigation of hyperfine interactions in immunoglobulin G with perturbed angular correlation spectroscopy using 111Cd2016 - SILVA, ANDREIA; AMARAL, ANTONIO; LAPOLLI, ANDRE; SAXENA, RAJENDRA; CARBONARI, ARTURHyperfine interaction parameters have been used to investigate physical properties of biomolecules from different isotypes of immunoglobulins G (IgG1, IgG2a and IgG2b). Immunoglobulin IgG1 induces a pattern of response type Th2 that corresponds to an allergic immunological response, whereas immunoglobulin IgG2 induces a pattern of response Th1 that corresponds to a cellular immunological response, suited for response against parasites. Hyperfine interactions were measured by perturbed gamma-gamma angular correlation (PAC) spectroscopy using 111In(111Cd) and 111mCd(111Cd) as probe nuclei. The measurements were carried out for both the complete and fragmented molecules at 295 K and 77 K, and both static as well as dynamic interactions were observed. Results of both measurements were used to calculate the rotational correlation time for each studied molecule. The complete and fragmented molecules showed different dynamic interactions. It was therefore conclude that the PAC technique is quite adequate for differentiating between the isotypes of immunoglobulins as well as their dynamic behavior if adequate nuclear probe is utilized with rigorous control of measuring conditions. The hyperfine parameters obtained are related to the physical properties of each molecule in an attempt to understand the difference in their biological function.Resumo IPEN-doc 16959 Measurements in DNA molecules using perturbed angular correlations spectroscopy2011 - SILVA, ANDREIA dos S.; AMARAL, ANTONIO A.; LAPOLLI, ANDRE L.; SAXENA, RAJENDRA N.; CARBONARI, A.W.Resumo IPEN-doc 16704 Measurements in DNA molecules using perturbed angular correlation spectroscopy2010 - SILVA, ANDREIA dos S.; AMARAL, ANTONIO A.; LAPOLLI, ANDRE L.; SAXENA, RAJENDRA N.; CARBONARI, ARTUR W.; GONCALVES, MARCOS B.Artigo IPEN-doc 15160 Application of perturbed angular correlation spectroscopy in IgG immunoglobulins2009 - SILVA, A.S.; AMARAL, A.A.; LAPOLLI, A.L.; CARBONARI, A.W.Artigo IPEN-doc 16856 Investigation of hyperfine interactions in hafnioum compounds with Fsup(1-), OHsup(1-), and EDTA ligants by perturbed 'gamma-gamma' angular correlation2011 - AMARAL, ANTONIO A.; SILVA, ANDREIA dos S.; LAPOLLI, ANDRE L.; CARBONARI, ARTUR W.; SAXENA, RAJENDRA N.Artigo IPEN-doc 15041 Study of dynamic behavior of EDTA molecule in solution using perturbed gamma-gamma angular correlation spectroscopy2009 - AMARAL, ANTONIO A.; SILVA, ANDREIA S.; CARBONARI, ARTUR W.; LAPOLLI, ANDRE L.