ALEXANDRE LUIZ DE SOUZA

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Variations in essential elements after malignant transformation of kidney epithelial tubular cells
2020 - BELLINI, MARIA H.; SOUZA, ALEXANDRE L. de; SILVA, FABIO F. da; GUILHEN, SABINE N.; FERREIRA, RAFAEL V. de P.; ARAUJO, LEANDRO G. de; OLIVEIRA, JOAO E. de; MARUMO, JULIO T.
Cell line-based research is a valuable tool for the study of cancer physiopathology and the discovery of new drugs for use in clinical practice. In this study, inductively coupled plasma mass spectrometry (ICP-MS) was used to estimate Ca, Co, Cu, Fe, K, Mg, Mn, Na, P, S, Se, and Zn in epithelial tubular cells (HK-2) and kidney tumor cells (Caki-1 cells). The most relevant difference was a decrease in the contents of Ca, Cu, Fe, K, Mg, Mn, Na, P, S, and Zn. A significant accumulation of Co was also detected in Caki-1 cells. The fold change variation of each element concentration between HK-2 and Caki-1 cells was Ca (‒0.40), Co (1.37), Cu (‒0.68), Fe (‒0.56), K (‒0.40), Mg (‒0.41), Mn (-0.54), Na (‒0.33), P (‒0.31), S (‒0.26), and Zn (‒0.73). These findings indicate that the elements mainly affect the metabolic pathways of epithelial kidney cells. Thus, our findings open a new avenue for RCC target therapy