OSVALDO LUIZ DA COSTA
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Artigo IPEN-doc 29832 A new 124Xe irradiation system for 123I production2023 - COSTA, OSVALDO L. da; BARCELLOS, HENRIQUE; MATSUDA, HYLTON; SUMIYA, LUIZ C. do A.; JUNQUEIRA, FERNANDO de C.; MATSUDA, MARGARETH M.N.; LAPOLLI, ANDRE L.Since 2001, Nuclear and Energy Research Institute IPEN-CNEN has produced weekly ultrapure iodine-123, using a manual irradiation system, fully developed in IPEN. Iodine-123 radiopharmaceuticals have been produced and distributed to hospitals and clinics of nuclear medicine, where several diagnostic imaging procedures for thyroid, brain and cardiovascular functions are performed. Due to the short half-life and emission of low-energy photons, this radioisotope becomes suitable for diagnosis in children. In the present work, the technical and constructive aspects of a new fully automated irradiation system, dedicated to 123I routine production, employing enriched xenon-124 gas as the target material is presented. This new system consists of a target, a water and helium cooling system, a cryogenic system, an electric power system, and a control and process monitoring unit, composed of supervisory software, connected to a programmable logic controller via personal computer. In this new concept, there is no need for human intervention during radioisotope production, reducing the possibility of eventual failures or incidents involving radioactive material. By using this new system, a specific yield of 2.70 mCi/μAh per irradiation was achieved in validation runs, and after three years of routine production of iodine- 123, the system showed reliability and resilience.Artigo IPEN-doc 29113 Design and assembly of an XY-type beam current monitor for cyclotron accelerators2023 - BARCELLOS, HENRIQUE; MATSUDA, HYLTON; LAPOLLI, ANDRE L.; SUMIYA, LUIZ C. do A.; JUNQUEIRA, FERNANDO de C.; COSTA, OSVALDO L. daA water-cooled XY-type beam current monitor was designed, manufactured and assembled in a cyclotron accelerator beam transport line. Tests were performed, demonstrating that apparatus is an instrument of great assistance in proton beam position. The XY-type beam current monitor has been widely used in liquid target irradiations, employing irradiation system which were originally designed for irradiations on 18 MeV cyclotron accelerator (Cyclone 18, IBA) only, however, with this apparatus, the target may be exchanged between the 30 MeV (Cyclone 30, IBA) and 18 MeV cyclotrons.Artigo IPEN-doc 27743 Gamma spectrometry of iodine-125 produced in IEA-R1 nuclear reactor, using HPGe detector and fixation into epoxy matrix disc2021 - COSTA, OSVALDO L. da; SOUZA, DAIANE C.B. de; CASTANHO, FABIO G.; FEHER, ANSELMO; MOURA, JOÃO A.; SOUZA, CARLA D.; OLIVEIRA, HENRIQUE B.; MADUAR, MARCELO F.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.Few places in the world produce iodine-125. In Brazil, the first production was achieved by using the IEA-R1 nuclear reactor located at Nuclear and Energy Research Institute – IPEN. To verify the quality of iodine-125 produced, and the amount of contaminants such as iodine-126, cesium-134 and caesium-137 among others, iodine-125 samples were immobilized into epoxy matrix disc, with the same geometry of a barium-133 reference radioactive source, used to calibrate an HPGe detector. The HPGe detector has a thin carbon composite window, which allows measure the iodine-125 photopeaks, between 27.1 and 35.4 keV. The method employed here was successful in producing and measurement of iodine-125.Artigo IPEN-doc 27362 New core configuration for the fabrication of 125I radioactive sources for cancer treatment2020 - SOUZA, CARLA D. de; ZEITUNI, CARLOS A.; FEHER, ANSELMO; MOURA, JOÃO A.; COSTA, OSVALDO L. da; ANGELOCCI, LUCAS V.; ROSTELATO, MARIA E.C.M.In order to provide prostate brachytherapy treatment for more Brazilian men, IPEN is building a laboratory for the manufacture of radioactive sources. The new methodology for the production of iodine-125 seeds with yield 71.7% ± 5.3%. Points of importance were evaluated/discussed: photo-sensibility, reaction vial type, the substitution for iodine-131, pH, and solution volume. The surface was analyzed by FTIR and EDS. At the end, a Monte Carlo-MCNP6 simulation was performed to evaluate the TG-43 parameters.