LUCAS RAMOS DE PRETTO
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Artigo IPEN-doc 28418 Rehabilitation of patients after COVID-19 recovery2021 - IMAMURA, MARTA; MIRISOLA, ALINE R.; RIBEIRO, FERNANDO de Q.; DE PRETTO, LUCAS R.; ALFIERI, FABIO M.; DELGADO, VINICIUS R.; BATTISTELLA, LINAMARA R.OBJECTIVES: As patients recovering from the novel coronavirus disease 2019 (COVID-19) present with physical, respiratory, cognitive, nutritional, and swallowing-related impairments and mental health complications, their rehabilitation needs are complex. This study aimed to describe the demographic, clinical, and functional status after the discharge of COVID-19 survivors who underwent intensive multidisciplinary inpatient rehabilitation at the Physical and Rehabilitation Medicine Institute of the University of Sao Paulo Medical School General Hospital and Lucy Montoro Rehabilitation Institute. We determined the most important factors related to the length of inpatient rehabilitation treatment and present the functional outcomes. METHODS: This was a retrospective study based on electronic medical records. In addition to the severity of COVID-19 and length of hospital stay for the management of COVID-19 and comorbidities, we collected sociodemographic data including age, sex, height, and weight. Functional assessments were performed using the Functional Independence Measure (FIM); Short Physical Performance Battery; Montreal Cognitive Assessment; Depression, Anxiety and Stress Scale; Revised Impact of Events Scale; bioelectrical impedance; Functional Oral Intake Scale; oropharyngeal dysphagia classification; and nutritional assessment. RESULTS: There was a significant improvement in FIM before and after inpatient rehabilitation treatment (p<0.0001). Muscle strength and walking capacity were significantly improved (p<0.01). The most important factors related to the length of inpatient rehabilitation treatment were improvement in FIM scores (Spearman’s r=0.71) and gain in lean mass (Spearman’s r=0.79). CONCLUSIONS: Rehabilitation of patients after COVID-19 recovery improves their functional status and should be considered in the post-acute phase for selected patients with COVID-19.Artigo IPEN-doc 23079 Antimicrobial photodynamic therapy combined to periodontal treatment: experimental model2017 - BELINELLO-SOUZA, ESTEFANI L.; ALVARENGA, LETICIA H.; LIMA-LEAL, CINTIA; ALMEIDA, PATRICIA; LEITE, CAROLINA G.; LIMA, TAIRINE R.; GODOY-MIRANDA, BIANCA; PREVIATI-OLIVEIRA, JHOSEPHER; PRETTO, LUCAS de; FREITAS, ANDERSON Z. de; FERNANDES, ADJACI U.; MARCOS, RODRIGO L.; PRATES, RENATO A.tBackground: Antimicrobial photodynamic therapy (aPDT) has been used as an adjuvant treatment forperiodontitis. It combines a photosensitizer with a light source to induce reactive oxygen species and killmicrobial cells. PpNetNI is a protoporphyrin derivative, and it has a chemical binding site at biofilm andgreat affinity to microbial cells. The aim of this study was to investigate the effects of aPDT as an adjuvanttreatment for periodontitis.Methods: Thirty healthy male rats Wistar (Rattus norvegicus) were used in this study (Approved by UNI-NOVE Ethical committee AN0029/2015). Periodontitis was induced by placing a cotton ligature aroundthe first mandibular molar in a subgengival position. The contralateral mandibular first molar receivedneither a ligature nor any treatment, and was used as a control. After 7 days, the ligature was removedand all animals received scaling and root planing (SRP) and were divided according to the following treat-ments: SRP group (received SRP and irrigation with PpNetNI, 10 M) and aPDT group (PpNetNI 10 Mfollowed by LED irradiation). aPDT was performed with a LED (630 nm) with an output power of 400 mW(fluence-rate 200 mW/cm2; fluence 18 J/cm2). Rats were euthanized at 24 h, 48 h and 7 days postopera-tively. The area of bone loss in vestibular region of the first molar was evaluated by Optical CoherenceTomography (OCT, THORLABS LTD., Ely, UK). Data were analyzed statistically (ANOVA and Tukey tests,p < 0.05).Results: The animals treated by aPDT showed bone gain of approximately 30% compared to the SRP groupfollowing 7 days from the treatment.Conclusion: aPDT promoted bone recovery 7 days after periodontal intervention.