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  • Artigo IPEN-doc 26266
    Correlation analysis of inorganic elements in whole blood of GRMD dogs using INAA
    2019 - METAIRON, SABRINA; ZAMBONI, CIBELE B.; SILVA, DALTON G.N. da
    Instrumental neutron activation analysis technique (INAA) has been used to determine Br, Ca, Cl, Cr, Fe, K, Mg, Na, P and S concentrations in whole blood of GRMD dogs’ samples from control, carrier and affected dogs (treated and untreated). The GRMD dogs are relevant as an experimental model for Duchenne Muscular Dystrophy (DMD), which is the most severe and prevalent type of muscular dystrophy. Muscle weakness, premature death and instability of the membrane that involves the muscle fibers - causing functional/structural abnormalities and cell death - are main characteristics of this genetic disease. To show in more details the alterations that this disease may cause in whole blood, correlations matrixes were generated for control, carried and affected groups permitting a comparison between them. The results emphasize physiologic differences for K and Mg and suggest that Br results are altered, emphasizing a constant monitoring need. Other than that, these results may help the researchers to evaluate the efficiency of new treatments and to compare the advantages of different treatment approaches before performing tests in patients with muscular dystrophy.
  • Artigo IPEN-doc 20780
    Investigation of Ca and Mg in blood of dystrophic animal model using NAA
    2013 - METAIRON, SABRINA; ZAMBONI, CIBELE B.; SUZUKI, MIRIAM F.; BUENO JUNIOR, C.R.; ANDRADE, T.O.; LANDINI, V.; CANGUSSU, E.B.; CAETANO, H.V.A.; ZATZ, CAETANO M.
  • Artigo IPEN-doc 16979
    Correlation analysis of inorganic elements in biological tissues of DMDsup(mdx)/J mice using INAA
    2011 - METAIRON, SABRINA; ZAMBONI, CIBELE B.; SUZUKI, MIRIAM F.; BUENO JUNIOR, CARLOS R.; SANT'ANNA, OSVALDO
  • Artigo IPEN-doc 16874
    Correlation analysis of inorganic elements in biological tissues of DMDsup(mdx)/J mice using INAA
    2011 - METAIRON, SABRINA; ZAMBONI, CIBELE B.; SUZUKI, MIRIAM F.; BUENO JUNIOR, CARLOS R.; SANT'ANNA, OSVALDO A.