NATANAEL GOMES DA SILVA
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
Artigo IPEN-doc 30354 Radioactive gold nanoparticles coated with BSA2024 - BARBEZAN, ANGELICA B.; ROSERO, WILMMER A.A.; VIEIRA, DANIEL P.; RIGO, MARIA E.Z.; SILVA, GIOVANA D. da; RODRIGUES, ALEX A.; ALMEIDA, LUIS F. de; SILVA, FABIO F.A. da; RIVERA, ANDY G.; SILVA, NATANAEL G. da; BERNARDES, EMERSON S.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.Background: Nanotechnology has revolutionized medicine, especially in oncological treatments. Gold nanoparticles (AuNPs) stand out as an innovative alternative due to their biocompatibility, potential for surface modification, and effectiveness in radiotherapeutic techniques. Given that prostate cancer ranks as one of the leading malignancies among men, there's a pressing need to investigate new therapeutic approaches. Methods: AuNPs coated with bovine serum albumin (BSA) were synthesized and their cytotoxicity was assessed against prostate tumor cell lines (LNCaP and PC-3), healthy prostate cells (RWPE-1), and endothelial control cells (HUVEC) using the MTS/PMS assay. For in vivo studies, BALB/C Nude mice were employed to gauge the therapeutic efficacy, biodistribution, and hematological implications post-treatment with BSA-coated AuNPs. Results: The BSA-coated AuNPs exhibited cytotoxic potential against PC-3 and LNCaP lines, while interactions with RWPE-1 and HUVEC remain subjects for further scrutiny. Within animal models, a diverse therapeutic response was observed, with certain instances indicating complete tumor regression. Biodistribution data emphasized the nanoparticles' affinity towards particular organs, and the majority of hematological indicators aligned with normative standards. Conclusions: BSA-coated AuNPs manifest substantial promise as therapeutic tools in treating prostate cancer. The present research not only accentuates the nanoparticles' efficacy but also stresses the imperative of optimization to ascertain both selectivity and safety. Such findings illuminate a promising trajectory for avant-garde therapeutic modalities, holding substantial implications for public health advancements.Artigo IPEN-doc 17842 Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core2011 - NUNEZ, EUTIMIO G.F.; FAINTUCH, BLUMA L.; TEODORO, RODRIGO; WIECEK, DANIELLE P.; SILVA, NATANAEL G.; PAPADOPOULOS, MINAS; PELECANOU, MARIA; PIRMETTIS, IOANNIS; OLIVEIRA FILHO, RENATO S. de; DUATTI, ADRIANO; PASQUALINI, ROBERTO; QUEIROZ, RODRIGO G.Artigo IPEN-doc 14527 Influence of colloid particle profile on sentinel lymph node uptake2009 - NUNEZ, EUTIMIO G.F.; FAINTUCH, BLUMA L.; TEODORO, RODRIGO; WIECEK, DANIELLE P.; MARTINELLI, JOSE R.; SILVA, NATANAEL G. da; CASTANHEIRA, CLAUDIA E.; OLIVEIRA FILHO, RENATO S. de; PASQUALINI, ROBERTOArtigo IPEN-doc 15709 Controle de qualidade EC sup(99m)Tc: determinação de pureza radioquímica e investigação da influencia de impurezas na biodistribuição2010 - ALMEIDA, ERIKA V.; MONTEIRO, ELISIANE G.; ALVES, EDSON V.; SILVA, NATANAEL G. da; FUKUMORI, NEUZA T.O.; BARBOZA, MARYCEL F. de; MENGATTI, JAIR; MATSUDA, MARGARETH M.N.; VASCONCELLOS, MARINA B.A.Artigo IPEN-doc 17554 Método cintilográfico não invasivo para estudo de biodistribuição de radiofármacos2011 - ALMEIDA, ERIKA V.; SILVA, NATANAEL G.; FREIRE, ANTONIO C.; MONTEIRO, ELISIANE de G.; BENEDETTI, STELLA; MURAMOTO, EMIKO; FUKUMORI, NEUZA T.O.; MATSUDA, MARGARETH M.N.; VASCONCELLOS, MARINA B.A.Artigo IPEN-doc 17848 Size and specificity of radiopharmaceuticals for sentinel lymph node detection2011 - NUNEZ, EUTIMIO G.F.; TEODORO, RODRIGO; WIECEK, DANIELLE P.; SILVA, NATANAEL G. da; MARTINELLI, JOSE R.; OLIVEIRA FILHO, RENATO S. deArtigo IPEN-doc 18085 Combining dose and injection volume for good performance of a specific radiopharmaceutical for sentinel node detection2012 - NUNEZ, EUTIMIO G.F.; OLIVEIRA, ERICA A. de; SILVA, NATANAEL G. da; OLIVEIRA FILHO, RENATO S. de