CARLA DARUICH DE SOUZA

CARLA DARUICH DE SOUZA

(Fonte: Lattes)

Resumo

Bsc in Medical Physics from UNESP in Botucatu Compleated at IPEN, University of São Paulo: 1) Master's Degree: Comparison between methods for fixing iodine-125 on silver substrate for fabricating sources used in Brachytherapy / 2) PhD: Parameters for production of iodine-125 sources used in brachytherapy and "sandwich" doctorate: Washington State University - training in radiochemistry and organic chemistry / 3) Post doctorate: Production of nanosources for the treatment of cancer / 4) Project: Analysis of methods to obtain / produce nuclear material for use in a radioisotope thermoelectric generator (RTG)/ Advisor of the Professional Master's Degree in Radiation Technology in Health / Professor of the Professional Master Program in the disciplines Dosimetry for Radiotherapy and Radiotherapy Fundamentals / Professor of the Academic Master Program in the discipline TNA5805 - Brachytherapy: Fundamentals, Production, Application, Dosimetry and Quality Research Associate of KAERI - Korean Atomic Energy and Research Institute (Text obtained from the Currículo Lattes on October 6th 2021)

Formada em Física Médica pela UNESP em Botucatu Realizado no IPEN-USP/ SP: 1) Mestrado: Comparação entre métodos de fixação do iodo-125 em substrato de prata para confecção de fontes utilizadas em Braquiterapia / 2) Doutorado: Parâmetros para produção de confecção de fontes de iodo-125 utilizadas em Braquiterapia e Doutorado sanduíche: Washington State University - treinamento em radioquímica / 3) Pós doutorado: Produção de nanofontes para tratamento de câncer / 4) Projeto: Análise de formas de obtenção/produção do material nuclear para utilização em um gerador termoelétrico radioisotópico (RTG)/ Orientadora do Mestrado Profissional de Tecnologia das Radiações na Saúde/ Professora do Mestrado Profissional nas disciplinas Dosimetria para Radioterapia e Fundamentos de Radioterapia/ Professora do Mestrado Acadêmico na disciplina TNA5805 - Braquiterapia: Fundamentos, Produção, Aplicação, Dosimetria e Qualidade Research Associate do KAERI - Korean Atomic Energy and Research Institute (Texto extraído do Currículo Lattes em 06 out. 2021)

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Radioactive seed localization for nonpalpable breast lesions
2024 - FERREIRA, HORTENCIA H.J.; SOUZA, CARLA D. de; POZZO, LORENA; RIBEIRO, MARTHA S.; ROSTELATO, MARIA E.C.M.
Background: This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety, and logistical outcomes. The protocol is registered in PROSPERO with the number CRD42022299726. Methods: A search was conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and clinicaltrials.gov databases, in addition to a manual search in the reference list of relevant articles, for randomized clinical trials and cohort studies. Studies selected were submitted to their own data extraction forms and risk of bias analysis according to the ROB 2 and ROBINS 1 tools. A meta-analysis was performed, considering the random effect model, calculating the relative risk or the mean difference for dichotomous or continuous data, respectively. The quality of the evidence generated was analyzed by outcome according to the GRADE tool. Overall, 46 articles met the inclusion criteria and were included in this systematic review; of these, 4 studies compared RSL and ROLL with a population of 1550 women, and 43 compared RSL and WGL with a population of 19,820 women. Results: The results showed that RSL is a superior method to WGL in terms of surgical efficiency in the impalpable breast lesions’ intraoperative localization, and it is at least equivalent to ROLL. Regarding security, RSL obtained results equivalent to the already established technique, the WGL. In addition to presenting promising results, RSL has been proven to be superior to WGL and ROLL technologies.
Gold nanoparticle applied to brachytherapy
2019 - GONZALEZ, ANDREZA A.D.C.C.; SOUZA, CARLA D.; ARCOS, WILMER A.; RODRIGUES, BRUNA T.; DOMINGUES, PAULO R.; SPINOSA, TATYANA B.; ROSTELATO, MARIA E.C.M.
Cancer is a global public health problem, that consists in a disease is characterized by the uncontrolled growth of anomalous cells that impair the functioning of the body. One of the treatments for cancer is the brachytherapy. This technique a non-invasive treatment in which the radiation is placed close or in contact with the region to be treated, brachytherapy may save the healthy tissues and consequently reduces the amount of side effects. An unexplored strand is nanobrachytherapy, that unites the advantages of brachytherapy with the small size in the nanoparticle (NP), resulting in an even less invasive treatment. Nanotechnology is the science that studies the properties of nanometric materials with the aim of creating new materials with different properties of interest. In view of the synthesis of the NP and their applicabilities, there is a fundamental role that is made to coatings, which have the function of avoiding the aggregation of particles, stabilize and also control their functional properties. Besides being able to add molecules of interest, such as antibiotics and anti-inflammatories. Among the range of coatings, the most outstanding are polyethylene glycol (PEG). PEG improves the surface properties of NP and presents high stability under biomedical conditions. The NP have their size controlled, which facilitates their penetration into the vasculature, in addition to being a non-toxic coating. After the synthesis of gold nanoparticles (Au-NP) was developed, PEG were successfully incorporated into the surface. Incorporation was confirmed by DLS, FT-IR and HRTEM.
Coatings of nanoparticles applied to brachytherapy treatments
2017 - GONZALEZ, ANDREZA A.D.C.C.; ROSTELATO, MARIA E.C.M.; SOUZA, CARLA D.; RODRIGUES, BRUNA T.; SOUZA, DAIANE C.B.; ZEITUNI, CARLOS A.; NOGUEIRA, BEATRIZ R.
Implementation of a thermoluminescence dosimetric laboratory for brazilian brachytherapy sources
2011 - MOURA, E.S.; ZEITUNI, C.A.; SAKURABA, R.K.; MANZOLI, J.E.; MOURA, J.A.; COSTA, O.L.; SOUZA, C.D.; FEHER, A.; ROSTELATO, M.E.C.M.
Methodology study for fixation of radioactive iodine in polymeric substrate for brachytherapy sources
2015 - RODRIGUES, BRUNA T.; ROSTELATO, MARIA E.C.M.; SOUZA, CARLA D.; TIEZZI, RODRIGO; SOUZA, DAIANE B. de; BENEGA, MARCOS A.G.; SOUZA, ANDERSON S. de; PELEIAS JUNIOR, FERNANDO S.; ZEITUNI, CARLOS A.; FERNANDES, VAGNER; MELO, EMERSON R. de; CAMARGO, ANDERSON R. de
Estudo e desenvolvimento de metodologia para fixação de iodo radioativo em substrato polimérico para confecção de fontes utilizadas em braquiterapia
2014 - RODRIGUES, BRUNA T.; SOUZA, CARLA D.; BENEGA, MARCOS A.G.; SOUZA, ANDERSON S.; ROSTELATO, MARIA E.C.M.; ZEITUNI, CARLOS A.; TIEZZI, RODRIGO; PELEIAS, FERNANDO S.; SOUZA, DAIANE C.; SILVA, THAIS H.
Study of the positioning influence in the water activity measurement during leak test of iodine-125 seeds
2014 - MOURA, JOAO A.; FEHER, ANSELMO; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.; CALVO, WILSON A.P.; COSTA, OSWALDO L.; SOUZA, CARLA D.; JUNIOR, DIB K.; CAMARGO, ANDERSON R.
Sementes de iodo-125: prototipo brasileiro
2009 - SOUZA, C.D.; ZEITUNI, C.A.; MOURA, J.A.; MOURA, E.S.; NAGATOMI, H.R.; FEHER, A.; SILVA, C.P.G.; ROSTELATO, M.E.C.M.
Development of irradiation support devices for production of brachytherapy seeds
2013 - MATTOS, FABIO R.; ROSTELATO, MARIA E.C.M.; ZEITUNI, CARLOS A.; SOUZA, CARLA D.; MOURA, JOAO A.; PELEIAS JUNIOR, FERNANDO S.; KARAN JUNIOR, DIB; FEHER, ANSELMO; OLIVEIRA, TIAGO B.; BENEGA, MARCOS A.G.
Comparação entre a utilização de sementes soltas e em cordas poliméricas em braquiterapia prostática no Brasil
2012 - PELEIAS JUNIOR, F.S.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.; SOUZA, C.D.; MATTOS, F.R.; BENEGA, M.A.G.