VERA MAURA FERNANDES DE LIMA
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Artigo IPEN-doc 23177 Extracellular matrix and its role in conveying glial/neural interactions in health and disease2017 - LIMA, VERA M.F. de; HANKE, WOLFGANGWe review the concepts and findings that may be related to the occurrence of non-linear glial/neural dynamics involving interactions between polyelectrolytes of the extracellular matrix and the basement membranes that cover the endfeet of glia at CNS interfaces. Distortions of perception and blocking of learning expressed in functional syndromes are interpreted as macroscopic electrochemical patterns that emerge in grey matter through glial/neural interactions.Artigo IPEN-doc 22994 Macroscopic self-organized electrochemical patterns in excitable tissue and irreversible thermodynamics2016 - LIMA, VERA M.F. de; HANKE, WOLFGANGIn this paper we make the assertion that the key to understand the emergent properties of excitable tissue (brain and heart) lies in the application of irreversible thermodynamics. We support this assertion by pointing out where symmetry break, phase transitions both in structure of membranes as well as in the dynamic of interactions between membranes occur in excitable tissue and how they create emergent low dimensional electrochemical patterns. These patterns are expressed as physiological or physiopathological concomitants of the organ or organism behavior. We propose that a set of beliefs about the nature of biological membranes and their interactions are hampering progress in the physiology of excitable tissue. We will argue that while there is no direct evidence to justify the belief that quantum mechanics has anything to do with macroscopic patterns expressed in excitable tissue, there is plenty of evidence in favor of irreversible thermodynamics. Some key predictions have been fulfilled long time ago and they have been ignored by the mainstream literature. Dissipative structures and phase transitions appear to be a better conceptual context to discuss biological self-organization. The central role of time as a global coupling agent is emphasized in the interpretation of the presented results.Artigo IPEN-doc 22395 The plastic glial-synaptic dynamics within the neuropil: A self-organizing system composed of polyelectrolytes in phase transition2016 - LIMA, VERA M.F. de; PEREIRA JUNIOR, ALFREDOArtigo IPEN-doc 17221 Modulation of CNS excitability by water movement. The Dsub(2)O effects on the non-linear neuron-glial dynamics2011 - LIMA, VERA M.F. de; HANKE, WOLFGANGArtigo IPEN-doc 18312 Gyroxin and its biological activity: effects on CNS basement membranes and endothelium and protease-activated receptors2012 - SILVA, J.A.A. da; SPENCER, P.; CAMILLO, M.A.; LIMA, V.M.F. deArtigo IPEN-doc 19842 Interaction of small cationic peptides with intact basement membranes. A study using intrinsic optical signals of click retinas2014 - LIMA, V.M.F. de; SPENCER, P.; HANKE, W.