MARA TANIA SILVA ALCANTARA

MARA TANIA SILVA ALCANTARA

Página do item completo

Resultados de Busca

Agora exibindo 1 - 8 de 8

Efeito do CMC no intumescimento de curativos de hidrogel à base de PVP com nanoprata
2019 - ALCANTARA, M.T.S.; OLIVEIRA, M.J.A.; LIERMANN, G.M.; LUGAO, A.B.
Hidrogéis de PVP são redes poliméricas tridimensionais, hidrofílicas, que apresentam propriedades de intumescimento e biocompatibilidade o que favorece seu uso como curativos. Por propiciar umidade no leito da ferida mantém o ambiente ideal para cicatrização, além de não aderir a ela. Por outro lado as nanopartículas de prata apresentam propriedades antimicrobianas e antiinflamatórias e o uso de radiação ionizante permite a reticulação e esterilização simultânea do curativo. O objetivo deste estudo foi avaliar o efeito do CMC no intumescimento de curativos de hidrogel com 22 e 80 ppm de nanopartículas de prata, reticulado por radiação ionizante, assim como avaliar a resistência mecânica dos curativos estudados. Os curativos foram avaliadas a partir de ensaios de fração gel, intumescimento e resistência mecânica. Os resultados indicaram um aumento importante no intumescimento do curativo com a adição de CMC, principalmente para o curativo com maior concentração de nanoprata, porém um menor grau de reticulação e consequentemente redução da sua resistência mecânica.
Effect of gamma irradiation on polymeric gel with glucantime and silver for the alternative treatment of cutaneous leishmania
2018 - OLIVEIRA, M.J.A.; VASQUEZ, P.A.S.; ALCANTARA, M.T.S.; LUGAO, A.B.
The drugs used to treat leishmania are in injectable form and the applications are painful that many patients give up during the treatment. The treatment requires hospitalization to monitor the side effects caused by the drugs, such as cardiac arrhythmia, renal dysfunction, among others. In addition to this situation, if the patient has symptoms such as cardiac arrhythmia, renal dysfunction they can not make use of the treatment. For these reasons finding new forms of treatments with minor side effects as alternative treatments for leishmaniasis has been the object of study of many research laboratories. The objective of this work was to analyze the effects of gamma irradiation on polymeric gel with glucantime and silver as the alternative treatment of cutaneous leishmania. In this case, the polymeric gel prevents the drug from falling directly into the bloodstream, avoiding the side effects, which would make unnecessary the patient's hospitalization. For the development of the gels was used, alginate, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), laponite clay, silver ions, and glucantime. The cobalt-60 source gamma irradiation was used for gel formation, silver nanoparticles and simultaneous sterilization. The physico-chemical characterizations were elemental analysis for quantification of Sb(V) and Sb(III) antimoniate, infrared spectroscopy (FTIR), dispersive energy spectrometry (EDS), transmission electron microscope (TEM). The results are promising, they show that the irradiation does not interfere with the drug's active principle, as expected in this study.
Hydrogels with silver nanoparticles for wound treatment
2017 - OLIVEIRA, MARIA J.A.; SANTOS, JONNATAN J.; TOMA, SERGIO H.; ALCANTARA, MARA T.S.; VASQUEZ, PABLO A.V.; ARAKI, KOITI; LUGAO, ADEMAR B.
In recent years, the study and preparation of nanoparticles have attracted considerable interest for both fundamental and applied research. In biomedical area, silver nanoparticles have been a vast field of study, although antimicrobial properties have originated from their medical application since 19th century. Since silver has had several uses and its enormous potential for the treatment of injuries. Silver-containing topcoats are an excellent option for topical microbial combat on wounds that present infection, as well as being an essential tool for controlling bacterial load. Among these coatings are the hydrogel dressings with silver nanoparticles that have broad spectrum of antimicrobial action. In vitro studies have demonstrated bactericidal activity in strains of antibiotic resistant microorganisms. The objective of this work is characterize hydrogels with silver nanoparticles, prepared using polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), used to treat wounds. A gamma radiation source cobalt-60 was used to crosslink the hydrogels, sterilize and form the silver nanoparticles simultaneously. Irradiation is recognized as a very viable tool because there is no need to add possibly harmful primers or crosslink that are difficult to remove. The results showed uniform distribution of the nanoparticles on the surface of the hydrogels, making it feasible for topical application.
Obtaining of a hydrogel gel dressing of PVP with nanosilver for deep and complex wounds
2017 - ALCANTARA, MARA T.S.; COUTINHO, CAMILA M.; OLIVEIRA, MARIA J.A.; MUNHOZ, MARA M.L.; LUGAO, ADEMAR B.
Introduction Chronic and some acute wounds of difficult treatment that challenge medical and nursing teams are classificadas como Complex wound (Ferreira et al., 2006). Due to the long cicatrization time and successive relapses, cause a problem social on patients' lives and economic a major impact on the health system (Azoubel et al., 2017). Throughout the world there has been a growing interest in the use of hydrogels for application as dressings in view that they are able to maintain the humidity of the wound, favoring the epithelialization of lesions and favoring the relief of pain. On the other hand, silver is an agent that has been used since ancient times, but it has been replaced after the discovery of antibiotics. However, with the advent of bacterial resistance to antibiotics and the development of nanotechnology, it has regained notoriety, since the clinical incidence of silver resistance remains low (Chopra, 2007).In addition to its bactericidal properties, silver nanoparticles (AgNPs) also have anti-inflammatory properties, which, allied to hydrogels’ advantages of maintaining moisture in the wound, represent a great advantage for use as a dressing. However, conventional dressings do not address the need for direct contact with the wound when this is a deep wound. The objective of this work was to obtain a hydrogel gel with silver nanoparticles for wound dressing, synthesized in situ by using ionizing radiation for gelation (crosslinking of PVP-Ag+ aqueous solution), synthesis of the AgNPs and simultaneous sterilization of the final product, able to fill the cavity of deep wounds, thus allowing the direct contact of the dressing with the lesioned walls. Methodology The gel was prepared from the mixture of PVP with plasticizers, water, and silver ions; next, the mixture was irradiated / sterilized by gamma-irradiation from a 60-Co source at a dose of 20 kGy. . Results The result of this work is a viscous and transparent gel (Fig. 1), easy to be applied, able to control pain since it reduces the local temperature due to evaporation of water. Fig. 1 - Hydrogel gel of PVP with silver nanoparticles for wound dressing. The studies are being continued with the aim of evaluating its stability and bactericidal activity.
Influence of gamma radiation on anphotericin b to possible incorporation into wound dressing
2016 - OLIVEIRA, M.J.A.; ESTRADA-VILLEGAS, G.M.; VASQUEZ, P.A.S.; ALCANTARA, M.T.S.; LUGAO, A.B.
In recent decades, many investigations have been addressed to develop alternative non–conventional treatments for several human body burns and wounds as well as new drug delivery systems in the treatment of diseases such as cutaneous leishmaniasis, always aiming to improve the quality of life of patients. Amphotericin B (Amph-B) is an antifungal drug often used intravenously for serious leishmaniasis treatment, but is well known for its severe and potentially lethal side effects. Hydrogels wound-dressing containing (Amph-B) will be able to offer an alternative to some patients that cannot be treated by conventional treatment due to (Amph-B) side effects. Many is these hydrogels are produced by gamma radiation in a simultaneous sterilization and cross-linking process. The hydrogels are useful as a wound-dressings, because they hold the wound moisture, are good as a drug delivery system and low cost production. The aim of this work is show the effects of gamma radiation (60 Cobalt) into (Amph-B) at different irradiation dose (10 kGy, 15kGy and 20kGy) and different temperatures (25ºC, 0ºC and -70ºC) to find the optimum conditions for future incorporation into hydrogels as an alternative treatment of cutaneous leishmaniasis. The study is very important to evaluate the molecule behavior when irradiated. The drug stability will be characterized by High Performance Liquid Cromatography (HPLC), UV-vis and Nuclear Magnetic Ressonance (NMR).
Hydrogel: the influence of oxygen on the properties of PVP membranes
2009 - ALCANTARA, M.T.S.; LUGAO, A.B.
The aim of this study is to verify the influence of dissolved oxygen on the synthesis of PVP hydrogels membranes. The hydrogels were prepared in different conditions (i.e., with oxygen dissolved and replacing the oxygen dissolved by nitrogen). The samples were crosslinked by gamma rays. The gel fraction and swelling kinetic in hydrogels membranes were analyzed to study the influence of natural oxygen in membranes prepared. The swelling results showed large differences on cross linking densities from samples irradiated with and without oxygen, however no difference was verified on gel fraction.
Obtencao de superabsorventes a partir de misturas de poliacrilamida e agua reticuladas com glioxal
2010 - NAIME, N.; BRANT, A.J.C.; GUADAGNIN, H.C.; ALCANTARA, M.T.S.; PONCE, P.; LUGAO, A.B.
Hidrogel com nanopartículas de prata para feridas infectadas com bactéria multiresistente
2013 - LUGAO, ADEMAR B.; LINCOPAN, NILTON; SANTOS, PRISCILA M. dos; RIELLA, HUMBERTO G.; ALCANTARA, MARA T.S.