MARA TANIA SILVA ALCANTARA
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Resumo IPEN-doc 25273 Effect of gamma irradiation on polymeric gel with glucantime and silver for the alternative treatment of cutaneous leishmania2018 - OLIVEIRA, M.J.A.; VASQUEZ, P.A.S.; ALCANTARA, M.T.S.; LUGAO, A.B.The drugs used to treat leishmania are in injectable form and the applications are painful that many patients give up during the treatment. The treatment requires hospitalization to monitor the side effects caused by the drugs, such as cardiac arrhythmia, renal dysfunction, among others. In addition to this situation, if the patient has symptoms such as cardiac arrhythmia, renal dysfunction they can not make use of the treatment. For these reasons finding new forms of treatments with minor side effects as alternative treatments for leishmaniasis has been the object of study of many research laboratories. The objective of this work was to analyze the effects of gamma irradiation on polymeric gel with glucantime and silver as the alternative treatment of cutaneous leishmania. In this case, the polymeric gel prevents the drug from falling directly into the bloodstream, avoiding the side effects, which would make unnecessary the patient's hospitalization. For the development of the gels was used, alginate, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), laponite clay, silver ions, and glucantime. The cobalt-60 source gamma irradiation was used for gel formation, silver nanoparticles and simultaneous sterilization. The physico-chemical characterizations were elemental analysis for quantification of Sb(V) and Sb(III) antimoniate, infrared spectroscopy (FTIR), dispersive energy spectrometry (EDS), transmission electron microscope (TEM). The results are promising, they show that the irradiation does not interfere with the drug's active principle, as expected in this study.Artigo IPEN-doc 24184 Effect of gamma radiation on polyvinylpyrrolidone hydrogels2017 - OLIVEIRA, M.J.A.; VASQUEZ, P.A.S.; ALCANTARA, M.T.S.; MUNHOZ, M.M.L.; LUGAO, A.B.Polyvinylpyrrolidone (PVP) hydrogels have been investigated as drug delivery matrices for the treatment of wounds, such as cutaneous leishmaniasis, and matrices with silver nanoparticles for chronic wounds and burns. The preparation of such hydrogels can occur by various cross-linking methods, such as gamma, chemical, physical, among others. The most feasible for wound dressings is gamma irradiation from cobalt-60, because gamma irradiation simultaneously promotes crosslinking and sterilization, leaving the wound dressing ready for use. The objective of this work was to investigate the effect on physico- chemical properties of gamma radiation on PVP hydrogel according to the radiation absorbed dose variation. The PVP hydrogels were irradiated with doses of 5, 15, 25, 35, 45, 55, 65, 75 and 95kGy at dose rate of 5 kGy/h and characterized by swelling, thermogravimetric and mechanical analysis. Results shown a favorable dose range window for processing of these hydrogels related to the application. The results showed that mechanical strength was affected at doses starting at 25 kGy.Resumo IPEN-doc 16197 Hydrogel: the influence of oxygen on the properties of PVP membranes2009 - ALCANTARA, M.T.S.; LUGAO, A.B.The aim of this study is to verify the influence of dissolved oxygen on the synthesis of PVP hydrogels membranes. The hydrogels were prepared in different conditions (i.e., with oxygen dissolved and replacing the oxygen dissolved by nitrogen). The samples were crosslinked by gamma rays. The gel fraction and swelling kinetic in hydrogels membranes were analyzed to study the influence of natural oxygen in membranes prepared. The swelling results showed large differences on cross linking densities from samples irradiated with and without oxygen, however no difference was verified on gel fraction.Resumo IPEN-doc 19801 Hidrogel com nanopartículas de prata para feridas infectadas com bactéria multiresistente2013 - LUGAO, ADEMAR B.; LINCOPAN, NILTON; SANTOS, PRISCILA M. dos; RIELLA, HUMBERTO G.; ALCANTARA, MARA T.S.Artigo IPEN-doc 10629 Estudo da reticulacao induzida por radiacao ionizante de poli(vinil pirrolidona)(PVP)/carboximetil celulose (CMC)2005 - ALCANTARA, M.T.S.; CHIRINOS, H.; AMARAL, R.H.; ROGERO, S.O.; LUGAO, A.B.Artigo IPEN-doc 19590 Estudo das propriedades mecânicas de hidrógeis utilizando planejamento experimental2013 - ALCANTARA, MARA T.S.; TAQUEDA, MARIA E.S.; GIANNINI, DANIELLE R.; BRANT, ANTONIO J.C.; RIELLA, HUMBERTO G.; LUGAO, ADEMAR B.Artigo IPEN-doc 15157 The influence of water quality on properties of hydrogel membranes prapared by ionizing radiation2009 - ALCANTARA, MARA T.S.; SISTI, CRISTINA; FURUSAWA, HELIO A.; LUGAO, ADEMARArtigo IPEN-doc 17084 Effect of different plasticizers on poly(N-vinyl-2-pyrroplidone) hydrogels cross-linked by radiation2011 - ALCANTARA, MARA T.S.; GIANNINI, DANIELLE R.; BRANT, ANTONIO J.C.; RIELLA, HUMBERTO G.; LUGAO, ADEMAR B.Artigo IPEN-doc 18236 Influence of dissolution processing of PVA blends on the characteristics of their hydrogels synthesized by radiation - Part I: Gel fraction, swelling, and mechanical properties2012 - ALCANTARA, M.T.S.; BRANT, A.J.C.; GIANNINI, D.R.; PESSOA, J.O.C.P.; ANDRADE, A.B.; RIELLA, H.G.; LUGAO, A.B.