MARIA JOSE ALVES DE OLIVEIRA

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Nanocomposite polymer clay to support the release of drug
2017 - OLIVEIRA, MARIA J.A.; LUGAO, ADEMAR B.; PARRA, DUCLERC F.
It is estimated that there are about 300,00 products named biomaterials that are used in the area of Health. Although they are widely used they have yet to be optimized for therapeutic use. Hence, the objective of this work was to develop nanocomposites hydrogels with poly (vinyl alcohol) (PVAl), glucantime, chitosan and synthetic clay Laponite RD, processed by gamma irradiation. To compare the behavior of drug release two systems were compared, PVAl / chitosan / clay and PVAl / clay. The morphology of the nanocomposites hydrogel was understood by using characterization techniques: X-ray diffraction, scanning electron microscopy (SEM) and atomic force microscopy (AFM) and gel fraction. The release kinetics was analyzed at 37 °C for period of 48 hours. It was observed that the slower release of the drug occurs in the delivery system composed by PVAl / chitosan / clay with correlation of the crosslink type formed by chitosan.