VANESSA SILVA GRANADEIRO GARCIA
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Artigo IPEN-doc 29329 Toxicidade aguda e avaliação de riscos ecológicos de fármacos pertencentes a diferentes classes detectados em ambientes aquáticos2021 - TOMINAGA, F.K.; BOIANI, N.F.; GARCIA, V.S.G.; SILVA, T.T.; LEO, P.; BORRELY, S.I.Artigo IPEN-doc 29328 Avaliação da toxicidade da mistura de fármacos submetidos a irradiação por feixe de elétrons2021 - BOIANI, N.F.; SILVA, T.T.; TOMINAGA, F.K.; GARCIA, V.S.G.; BORRELY, S.I.Artigo IPEN-doc 29039 Acute and chronic ecotoxicological effects of pharmaceuticals and their mixtures in Daphnia similis2022 - TOMINAGA, FLAVIO K.; BOIANI, NATHALIA F.; SILVA, THALITA T.; GARCIA, VANESSA S.G.; BORRELY, SUELI I.Pharmaceuticals have increasingly received attention from the scientific community due to their growing intake, improved detection and potential ecological risks. Several pharmaceuticals, including antidepressants, anti-inflammatory and antidiabetic compounds and antibiotics, have been described as contaminants in different water matrices. In this context, the aim of the present study was to assess the acute and chronic effects of four classes of pharmaceuticals (acetylsalicylic acid, fluoxetine, metformin and ciprofloxacin) individually and in binary and quartenary mixture. Furthermore, the toxicity of binary mixtures containing the antidepressant fluoxetine was also evaluated. The results of the single acute and chronic toxicity assays indicate lower acetylsalicylic acid and higher fluoxetine toxicity towards Daphnia similis. Regarding the evaluated mixture toxicity, the nature of potential toxicological interactions was predicted by applying mathematical concentration addition and independent action models. The findings revealed both antagonistic and synergistic features, depending on the applied amounts and doses. Finally, the chronic assays performed with the quaternary mixture indicated the presence of a hormetic effect at low concentrations. In sum, the present study demonstrated that the effects of individual pharmaceuticals can underestimate the risk level of these contaminants in the environment.Artigo IPEN-doc 28902 Ecotoxicological approach of surfactants treated by ionizing radiation2021 - GARCIA, VANESSA S.G.; ROSA, JORGE M.; SILVA, THALITA T.; BORRELY, SUELI I.Removing surfactants from liquid effluents has been a fundamental issue since they are found in several industrial effluents, hospitals, restaurants, and even homes. When disposed into aquatic environmental, surfactants can implicate in significant changes, including several adverse effects to aquatic organisms. The present study was developed to assess the ecotoxicological effects of surfactants (anionic and nonionic) to aquatic organisms Vibrio fischeri bacteria, Daphnia similis crustacean. The ionizing radiation (Electron Beam Irradiation - EBI) was applied as a possible technology for the treatment of these contaminants in order to reduce acute toxic effects. The obtained data showed that the surfactants were toxic for both organisms, and the nonionic were more toxic than anionic. EB irradiation reduced surfactants toxicity by 40% acute toxic effects for nonionic surfactant and more than 70% for anionic, for both exposed organisms classes.Resumo IPEN-doc 28652 Avaliação da toxicidade de surfactantes não iônico e aniônico submetidos a tratamento por feixe de elétrons2021 - GARCIA, VANESSA S.G.; TOMINAGA, FLAVIO K.; BOIANI, NATHALIA F.; SILVA, THALITA T.; ROSA, JORGE M.; BORRELY, SUELI I.