VIVIANE PEREIRA GOULART
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Artigo IPEN-doc 22900 Chemometric methods applied to FTIR spectra to discriminate treated and non-treated cutaneous malignant lesions from healthy skin2016 - LIMA, CASSIO A.; GOULART, VIVIANE; ZEZELL, DENISEChemometric methods were used to differentiate FTIR spectra of treated and nontreated malignant lesions from healthy skin. We conclude that the method can be used to evaluate the biological changes promoted by photodynamic treatment.Artigo IPEN-doc 22306 Evaluation of squamous cell skin carcinoma using ATR-FTIR spectroscopy associated to cluster analysis2014 - LIMA, C.A.; GOULART, V.; ZEZELL, D.M.Cluster Analysis were used as an unsupervised classification technique to differentiate FTIR spectra of normal and tumor skin. The results shown satisfactory separation in samples analyzed, highlighting the potential of the technique for diagnostic purposes.Artigo IPEN-doc 20857 Biochemical changes in cutaneous squamous cell carcinoma submitted to PDT using ATR-FTIR spectroscopy2015 - LIMA, CASSIO A.; GOULART, VIVIANE P.; CASTRO, PEDRO A.A. de; CORREA, LUCIANA; BENETTI, CAROLINA; ZEZELL, DENISE M.Nonmelanoma skin cancers are the most common form of malignancy in humans. Between the traditional treatment ways, the photodynamic therapy (PDT) is a promising alternative which is minimally invasive and do not requires surgical intervention or exposure to ionizing radiation. The understanding of the cascade of effects playing role in PDT is not fully understood, so that define and understand the biochemical events caused by photodynamic effect will hopefully result in designing better PDT protocols. In this study we investigated the potential of the FTIR spectroscopy to assess the biochemical changes caused by photodynamic therapy after 10 and 20 days of treatment using 5-aminolevulinic acid (ALA) as precursor of the photosensitizer photoporphyrin IX (PpIX). The amplitude values of second derivative from vibrational modes obtained with FTIR spectroscopy showed similar behavior with the morphological features observed in histopathological analysis, which showed active lesions even 20 days after PDT. Thus, the technique has the potential to be used to complement the investigation of the main biochemical changes that photodynamic therapy promotes in tissue.Artigo IPEN-doc 16038 Effect of Nd:YAG laser on enamel resistance to demineralization when associated with fluoride application2010 - SANTOS, M.O.; GOULART, V.P.; CORREA, P.R.; ANA, P.A.; ZEZELL, D.M.Artigo IPEN-doc 15924 Composition and crystallographic changes on enamel when irradiated by Nd:YAG or Er,Cr:YSGG lasers and its resistance to demineralization when associated with fluoride2010 - ZEZELL, D.M.; ANA, P.A.; BENETTI, C.; GOULART, V.P.; BACHMANN, L.; TABCHOURY, C.P.M.; CURY, J.A.