New core configuration for producing Iodine 125 seeds

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dc.contributor.authorRODRIGUES, B.T.pt_BR
dc.contributor.authorROSTELATO, M.C.M.pt_BR
dc.contributor.authorSOUZA, C.D. dept_BR
dc.contributor.authorZEITUNI, C.pt_BR
dc.contributor.authorMOURA, E.S. dept_BR
dc.contributor.authorSOUZA, D.B. dept_BR
dc.contributor.authorTOZETTI, C.pt_BR
dc.contributor.authorRODRIGUES, B.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-04-27T14:46:00Z
dc.date.available2020-04-27T14:46:00Z
dc.date.issued2017pt_BR
dc.description.abstractPurpose: Cancer is one of the most complex public health problems. Prostate cancer is the second most common among men. In prostate brachytherapy use Iodine-125, which is fixated on a silver substrate, then inserted and sealed in a titanium capsule. This work proposes a new source configuration using epoxy resin substrate. Methods: Comparation and analysis methods were used to define the methodology for combining iodine-125 in polymers. The parameters were immersion time, reaction type, concentration of the adsorption solution, specific activity of the radioactive solution, need for carrier and chemical form of radioactive iodine. Results: The methodology developed with an epoxy resin was very good. The final radioactive intake on the resin was higher than 80%. The immobilization of the radioactive solution occurred in the matrix, without any loss or deposition of undesirable materials on its surface, as evidenced by the smear test. The material maintains its integrity when autoclaved at 140 °C. The curing process of the resin was 40 minutes. With the value of the initial activity of the Iodine solution by mass (774.2 lCi/g), it was possible to calculate the immobilization efficiency Average of 680 lCi/g. The immersion test in distilled water at room temperature did not exceed the limit allowed by ISO 9978, which is 5 nCi (185 Bq), proof of no leakage. In a computational simulation by the Monte Carlo Method, PENELOPE, the simulations were consistent with the values adopted by the literature for the GE Healthcare model 6711, which shows the value of the dose rate constant as 0, 965 cGy.U-1.h-1. Conclusion: The effective method for combining iodine-125 in epoxy resin was determinated. The major advantage was the high efficiency percentage fixation, around 82,1 3,2%, and the simplicity and safety of the process.pt_BR
dc.format.extent2828-2829pt_BR
dc.identifier.citationRODRIGUES, B.T.; ROSTELATO, M.C.M.; SOUZA, C.D. de; ZEITUNI, C.; MOURA, E.S. de; SOUZA, D.B. de; TOZETTI, C.; RODRIGUES, B. New core configuration for producing Iodine 125 seeds. <b>Medical Physics</b>, v. 44, n. 6, p. 2828-2829, 2017. DOI: <a href="https://dx.doi.org/10.1002/mp.12304">10.1002/mp.12304</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31135.
dc.identifier.doi10.1002/mp.12304pt_BR
dc.identifier.fasciculo6pt_BR
dc.identifier.issn0094-2405pt_BR
dc.identifier.orcid0000-0002-7303-6720pt_BR
dc.identifier.orcid0000-0003-2943-6097pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-1335-8864
dc.identifier.orcidhttps://orcid.org/0000-0002-7303-6720
dc.identifier.orcidhttps://orcid.org/0000-0003-2943-6097
dc.identifier.percentilfi72.481pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31135
dc.identifier.vol44pt_BR
dc.relation.ispartofMedical Physicspt_BR
dc.rightsclosedAccesspt_BR
dc.sourceAnnual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine, 59th, July 30 - August 03, 2017, Denver, USApt_BR
dc.subjectneoplasms
dc.subjectprostate
dc.subjectiodine 125
dc.subjectpolymers
dc.subjectepoxides
dc.subjectresins
dc.titleNew core configuration for producing Iodine 125 seedspt_BR
dc.typeResumos em periódicospt_BR
dspace.entity.typePublication
ipen.autorCARLA DARUICH DE SOUZA
ipen.autorDAIANE CRISTINI BARBOSA DE SOUZA
ipen.autorCARLOS ALBERTO ZEITUNI
ipen.autorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.autorBRUNA TEIGA RODRIGUES
ipen.codigoautor7717
ipen.codigoautor9273
ipen.codigoautor944
ipen.codigoautor7
ipen.codigoautor11600
ipen.contributor.ipenauthorCARLA DARUICH DE SOUZA
ipen.contributor.ipenauthorDAIANE CRISTINI BARBOSA DE SOUZA
ipen.contributor.ipenauthorCARLOS ALBERTO ZEITUNI
ipen.contributor.ipenauthorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.contributor.ipenauthorBRUNA TEIGA RODRIGUES
ipen.date.recebimento20-04
ipen.identifier.fi2.884pt_BR
ipen.identifier.ipendoc26913pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreResumo
relation.isAuthorOfPublication866434dc-2634-4567-8b4b-04e5ce06bf04
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relation.isAuthorOfPublication3b25db9e-d05b-4fe0-b2a1-ab6b0c67d5ab
relation.isAuthorOfPublication.latestForDiscovery3b25db9e-d05b-4fe0-b2a1-ab6b0c67d5ab
sigepi.autor.atividadeSOUZA, D.B. de:9273:230:Npt_BR
sigepi.autor.atividadeZEITUNI, C.:944:230:Npt_BR
sigepi.autor.atividadeSOUZA, C.D. de:7717:230:Npt_BR
sigepi.autor.atividadeROSTELATO, M.C.M.:7:230:Npt_BR
sigepi.autor.atividadeRODRIGUES, B.T.:11600:230:Spt_BR
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