Development of poly (n-vinyl-2-pyrrolidone) hydrogels containing nanosilver and laponite clay for modulation of neomycin
Carregando...
Data
2020
Data de publicação:
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Journal of Astrophysics & Aerospace Technology
Exportar
Resumo
These Biomaterials widely used in biomedicine as wound
dressings are composed by hydrogels. They offer ideal
conditions for wound treatment, such as maintaining the wound
environment humid, autolytic debridement, accelerated healing,
ability to absorb large amounts of fluids without losing their
physical integrity, drug release in a controlled manner
protecting infected wounds that are constantly exposed to
environment contaminated with microorganisms. These
dressings are formed by one or more polymeric components
which, when cross-linked, form three-dimensional networks.
They have a high degree of flexibility that is very similar to
natural living tissues. The general objective of this work was to
synthesize by radiation hydrogel membranes containing PVP,
PEG, agar, RD laponite in a neomycin and nanosilver release
system that promotes a synergistic action between these two
antimicrobial agents. Membranes with different concentrations
of polymer matrix / clay were produced by irradiation at a dose
of 25 kGy of gamma 60Co source, and characterized by
techniques: swelling analysis, thermogravimetric analysis
(TGA), differential scanning calorimetry (DSC), tensile tests,
parallel plate rheometry. It can be seen that G 'and G "are
approximately parallel within the studied range. G 'is greater
than G' 'and both showed little frequency dependence. This
performance is the expected for the gels, in which the elastic
behavior of the sample predominates over its viscous behavior.
The clay-polymer interactions increases gel cross-linking,
which provides an increase in their mechanical properties. In
parallel, nanoparticles of silver coupled to clay (Laponite) were
synthesized in which their properties were verified by means of
UV-Vis, MET, ICP-OES and microbiological activity. The
study of the microbiological activity of AgNPs-Laponite
nanoparticles on the reduction of microorganisms in culture
indicated that most of the nanoparticles, synthesized from the
reduction of silver ions on the surface of Laponite, have activity against Pseudomonas aeruginosa, Staphylococcus aureus,
Escherichia coli, Candida albicans.
Como referenciar
PARRA, DUCLERC F.; SANTOS, VINICIUS J. dos; TAMIÃO, ANGELICA. Development of poly (n-vinyl-2-pyrrolidone) hydrogels containing nanosilver and laponite clay for modulation of neomycin. Journal of Astrophysics & Aerospace Technology, v. 8, n. 2, p. 3-3, 2020. Disponível em: http://repositorio.ipen.br/handle/123456789/31833. Acesso em: 12 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.