Treating metabolic sundrome's metaflammation with low level light therapy: preliminary results
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2014
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MECHANISMS FOR LOW-LIGHT THERAPY, 9th
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Metabolic syndrome comprises a constellation of morbidities such as insulin resistance, hyperinsulinemia, atherogenic
dyslipidemia, dysglycemia and obesity (especially abdominal). Metabolic alterations are observed in major insulin target
organs, increasing the risk of cardiovascular diseases, type-2 diabetes and therefore mortality. Tissue alterations are
characterized by immune cells infiltrates (especially activated macrophages). Released inflammatory mediators such as
TNF-α induce chronic inflammation in subjects with metabolic syndrome, since inflammatory pathways are activated in
the neighboring cells. The intra-abdominal adipose tissue appears to be of particular importance in the onset of the
inflammatory state, and strategies contributing to modulate the inflammatory process within this adipose tissue can
mitigate the metabolic syndrome consequences. Considering the low level light therapy (LLLT) recognized benefits in
inflammatory conditions, we hypothesized this therapeutic approach could promote positive effects in modulating the
inflammatory state of metabolic syndrome. That being the scope of this study, male C57BL/6 mice were submitted to a
high-fat/high-fructose diet among 8 weeks to induce metabolic syndrome. Animals were then irradiated on the
abdominal region during 21 days using an 850 nm LED (6 sessions, 300 seconds per session, 60 mW output power,
~6 J/cm² fluence, ~19 mW/cm² fluence rate). Before and during treatment, blood was sampled either from the retroorbital plexus or from tail puncture for glucose, total cholesterol and triglycerides analysis. So far our results indicate no
alterations on these metabolic parameters after LLLT. For further investigations, blood was collected for plasma
inflammatory cytokine quantification and fresh ex vivo samples of liver and intra-abdominal adipose tissue were
harvested for immunohistochemistry purposes.
Como referenciar
YOSHIMURA, TANIA M.; KATO, ILKA T.; DEANA, ALESSANDRO M.; RIBEIRO, MARTHA S. Treating metabolic sundrome's metaflammation with low level light therapy: preliminary results. In: HAMBLIN, MICHAEL R. (ed.); CARROLL, JAMES D. (ed.); ARANY, PRAVEEN (ed.). In: MECHANISMS FOR LOW-LIGHT THERAPY, 9th, February 1, 2014, San Francisco, California, United States. Proceedings... p. 89320J-1 - 89320J-9. (SPIE Proceedings Series, 8932). DOI: 10.1117/12.2040901. Disponível em: http://repositorio.ipen.br/handle/123456789/23711. Acesso em: 12 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.