Comparative study of the cytotoxicity of gold nanoparticles produced by green nanotechnology and by conventional methods

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dc.contributor.authorBATISTA, J.G.S.
dc.contributor.authorROGERO, S.O.
dc.contributor.authorLUGAO, A.B.
dc.contributor.editorBURITI, JOSUE da S.
dc.contributor.editorCRUZ, RITA de C.A.L.
dc.contributor.editorFOOK, MARCUS V.L.
dc.coverageNacionalpt_BR
dc.creator.eventoCONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGÃOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 15.; CONGRESSO LATINO AMERICANO DE ÓRGÃOS ARTIFICIAIS E BIOMATERIAIS, 10.pt_BR
dc.date.accessioned2019-02-06T13:34:15Z
dc.date.available2019-02-06T13:34:15Z
dc.date.evento22 a 25 de agosto, 2018pt_BR
dc.description.abstractResearchers and laboratories around the world have studied gold nanoparticles (AuNPs). In medicine, several studies demonstrate the applicability of gold nanoparticles in the treatment and diagnosis of cancer. Green nanotechnology uses phytochemical agents to synthesize and stabilize nanoparticles. Researchers have shown that some reducing phytochemicals such as mangiferin (MGF) and epigallocatechin-gallate (EGCG), in addition to reducing and stabilizing the gold nanoparticles, are able to functionalize them. These molecules have chemical groups that allow binding to overexpressed receptors on some types of tumor cells. Developed by the International Organization for Standardization (ISO-International Organization for Standardization), the set of known standards such as ISO 10993 addresses the safety of medical devices through the identification of diverse types of biocompatibility. The objective of this work was to compare the cytotoxicity of the AuNPs obtained through green nanotechnology and compare with data found in the literature of AuNPs synthetized by conventional methods such as Turkevich. The cytotoxicity assay was carried out by exposing the cell culture to the solutions of AuNPs in culture medium MEM (1:1) at 37 °C. The NCTC clone 929 cell line was acquired from Adolfo Lutz Institute cell bank. The cytotoxicity effect was evaluated by neutral red uptake (NRU) methodology according to the International Organization for Standardization (ISO). The results showed that the AuNPs obtained by green nanotechnology presented lower toxicity than those obtained by the Turkevich method using the same concentration of NaAuCl4 in the AuNPs synthesis. It is necessary to consider that the particles differ in size and hydrodynamic volume according to the data obtained in the physical chemical characterization of the AuNPs obtained by both methods.pt_BR
dc.event.siglaSLABO; COLAOBpt_BR
dc.format.extent196-196pt_BR
dc.identifier.citationBATISTA, J.G.S.; ROGERO, S.O.; LUGAO, A.B. Comparative study of the cytotoxicity of gold nanoparticles produced by green nanotechnology and by conventional methods. In: BURITI, JOSUE da S. (ed.); CRUZ, RITA de C.A.L. (ed.); FOOK, MARCUS V.L. (ed.). In: CONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGÃOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 15.; CONGRESSO LATINO AMERICANO DE ÓRGÃOS ARTIFICIAIS E BIOMATERIAIS, 10., 22 a 25 de agosto, 2018, João Pessoa, PB. <b>Resumo...</b> Belo Horizonte, MG: Sociedade Latino Americana de Biomateriais, Engenharia de Tecidos e Órgãos Artificiais, 2018. p. 196-196. Disponível em: http://repositorio.ipen.br/handle/123456789/29489.
dc.identifier.orcidaguardandopt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.orcidhttps://orcid.org/0000-0003-3396-6277
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29489
dc.localBelo Horizonte, MGpt_BR
dc.local.eventoJoão Pessoa, PBpt_BR
dc.publisherSociedade Latino Americana de Biomateriais, Engenharia de Tecidos e Órgãos Artificiaispt_BR
dc.rightsopenAccesspt_BR
dc.subjectantimitotic drugs
dc.subjecttoxicity
dc.subjectgold
dc.subjectnanoparticles
dc.subjectnanotechnology
dc.subjectbiological materials
dc.subjectbioassay
dc.subjecttumor cells
dc.titleComparative study of the cytotoxicity of gold nanoparticles produced by green nanotechnology and by conventional methodspt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorJORGE GABRIEL DOS SANTOS BATISTA
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorSIZUE OTA ROGERO
ipen.codigoautor10274
ipen.codigoautor339
ipen.codigoautor1266
ipen.contributor.ipenauthorJORGE GABRIEL DOS SANTOS BATISTA
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorSIZUE OTA ROGERO
ipen.date.recebimento19-02pt_BR
ipen.event.datapadronizada2018pt_BR
ipen.identifier.ipendoc25277pt_BR
ipen.notas.internasResumopt_BR
ipen.type.genreResumo
relation.isAuthorOfPublicationd71d578f-dbbd-4ff9-adf8-929b13d23037
relation.isAuthorOfPublication99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
relation.isAuthorOfPublicationadecaf83-1d61-4fa2-b7e6-4cf91494610d
relation.isAuthorOfPublication.latestForDiscoveryd71d578f-dbbd-4ff9-adf8-929b13d23037
sigepi.autor.atividadeBATISTA, J.G.S.:10274:740:Spt_BR
sigepi.autor.atividadeROGERO, S.O.:1266:740:Npt_BR
sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
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