Essential elements as biomarkers of acute kidney injury and spontaneous reversion

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dc.contributor.authorSILVA, REGIANE M. da
dc.contributor.authorKO, GUI MI
dc.contributor.authorSILVA, RINALDO F.
dc.contributor.authorVIEIRA, LUDMILA C.
dc.contributor.authorPAULA, RAFAEL V. de
dc.contributor.authorMARUMO, JULIO T.
dc.contributor.authorIKEGAMI, AMANDA
dc.contributor.authorBELLINI, MARIA H.
dc.coverageInternacionalpt_BR
dc.date.accessioned2017-10-05T11:39:20Z
dc.date.available2017-10-05T11:39:20Z
dc.date.issued2018pt_BR
dc.description.abstractAcute kidney injury (AKI) is an important health problem and can be caused by number of factors. The use of aminoglycosides, such as gentamicin, is one of these factors. Recently, an effort has been made to find biomarkers to guide treatment protocols. Inductively coupled plasma optical emission spectroscopy (ICP-OES) was used to estimate the contents of Ca, Cu, Fe, K, Mg, Mn, Na, P, and Zn in serum and urine of the healthy, AKI, and spontaneous recovery (SR) groups of animals. The animal model of AKI and SR was validated by measuring serum and urinary urea and creatinine. The quantitative determination of the elements showed a decrease in serum levels of Ca, and Fe in the AKI group (P<0.01 vs. healthy), with a return to normal levels in the SR group, without a significant difference between the healthy and SR groups. In the urine samples, there was a decrease in P and Na levels in the AKI group (P<0.001 and P<0.01 vs. healthy), but Ca levels were increased in this group compared with the healthy and SR groups (P<0.01). These findings indicate that mineral elements might be useful as biomarkers for AKI.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 14/19265-7pt_BR
dc.format.extent303-308
dc.identifier.citationSILVA, REGIANE M. da; KO, GUI MI; SILVA, RINALDO F.; VIEIRA, LUDMILA C.; PAULA, RAFAEL V. de; MARUMO, JULIO T.; IKEGAMI, AMANDA; BELLINI, MARIA H. Essential elements as biomarkers of acute kidney injury and spontaneous reversion. <b>Biological Trace Element Research</b>, v. 182, n. 2, p. 303-308, 2018. DOI: <a href="https://dx.doi.org/10.1007/s12011-017-1091-2">10.1007/s12011-017-1091-2</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/27833.
dc.identifier.doi10.1007/s12011-017-1091-2pt_BR
dc.identifier.fasciculo2
dc.identifier.issn0163-4984pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2852-6189
dc.identifier.orcidhttps://orcid.org/0000-0003-3010-9691
dc.identifier.percentilfi36.05en
dc.identifier.percentilfiCiteScore57.20
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/27833
dc.identifier.vol182
dc.relation.ispartofBiological Trace Element Researchpt_BR
dc.rightsopenAccesspt_BR
dc.subjectkidneys
dc.subjectinjuries
dc.subjectbiological markers
dc.subjectemission spectroscopy
dc.subjectplasma
dc.subjectoptical systems
dc.subjectantibiotics
dc.subjectrats
dc.subjecturine
dc.subjectcreatinine
dc.subjecturea
dc.subjectblood serum
dc.titleEssential elements as biomarkers of acute kidney injury and spontaneous reversionpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorLUDMILA CABREIRA VIEIRA
ipen.autorMARIA HELENA BELLINI MARUMO
ipen.autorAMANDA IKEGAMI
ipen.autorJULIO TAKEHIRO MARUMO
ipen.codigoautor8806
ipen.codigoautor1242
ipen.codigoautor14176
ipen.codigoautor826
ipen.contributor.ipenauthorLUDMILA CABREIRA VIEIRA
ipen.contributor.ipenauthorMARIA HELENA BELLINI MARUMO
ipen.contributor.ipenauthorAMANDA IKEGAMI
ipen.contributor.ipenauthorJULIO TAKEHIRO MARUMO
ipen.date.recebimento17-10pt_BR
ipen.identifier.fi2.431pt_BR
ipen.identifier.fiCiteScore4.0
ipen.identifier.ipendoc23209pt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublication088914ce-c20a-4900-a013-04d8f84fa275
relation.isAuthorOfPublication6a450cbf-91b1-4386-b4a8-7304afac99cc
relation.isAuthorOfPublicationc1a35160-e89c-4e34-8337-b21794e3f938
relation.isAuthorOfPublication4555167f-0f50-4308-be74-c5a0f15d5dda
relation.isAuthorOfPublication.latestForDiscovery088914ce-c20a-4900-a013-04d8f84fa275
sigepi.autor.atividadeVIEIRA, LUDMILA C.:8806:1120:Npt_BR
sigepi.autor.atividadeMARUMO, JULIO T.:826:1120:Npt_BR
sigepi.autor.atividadeIKEGAMI, AMANDA:14176:820:Npt_BR
sigepi.autor.atividadeBELLINI, MARIA H.:1242:820:Npt_BR
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