Gold nanoparticles stabilized with gum arabic for cancer treatment
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2019
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
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Cancer is a group of diseases characterized by
uncontrolled growth and abnormal spread of cells. The number of
deaths due to cancer is higher than the ones caused by AIDS, tuberculosis and malaria combined. Among the
different options of cancer treatment radiotherapy (teletherapy and brachytherapy) sta nds out. The presence of
gold nanoparticles (AuNPs) may enhance energy deposition for teletherapy treatment. The use of nanoparticles
for brachytherapy have been studied, and AuNPs is a good option once they can easily permeate tumor
vasculature and remain in tumors. However, the tumor uptake of AuNPs may be significantly reduced due the
attenuation with the formation of the protein coronas. The objective of this work is present the functionalization
of AuNPs with arabic gum (GA). GA is a biocompatible, non toxic, water soluble, natural gum obtained from
Acacia senegal tree. In this study, a synthesis of gold nanoparticles (AuNPs), based on Turkevich method, using
citrate (NaCit) solution as reducing agent and a HAuCl4 solution, under vigorously stirring and boiling
temperature, going from a light yellow to a wine red in three minutes. The functionalization of the nanoparticles
was performed with Arabic gum solutions, in three different concentrations , which were a dded under stirring to
the AuNPs already obtai ned. Samples were characterized to measure the size of the samples. Lower
concentrations o GA in the solution presented smaller coated particles (up to 45 nm).
Como referenciar
ROSERO, WILMMER A.A.; NOGUEIRA, BEATRIZ R.; SOUZA, CARLA D. de; GONZALEZ, ANDREZA A.D.C.C.; BARBEZAN, ANGELICA B.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M. Gold nanoparticles stabilized with gum arabic for cancer treatment. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 21-25, 2019, Santos, SP. Proceedings... Rio de Janeiro: Associação Brasileira de Energia Nuclear, 2019. p. 1946-1952. Disponível em: http://repositorio.ipen.br/handle/123456789/30592. Acesso em: 11 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.