Effects of Notch signaling pathway inhibition by dibenzazepine in acute experimental toxoplasmosis

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dc.contributor.authorBRICENO, MARISOL P.pt_BR
dc.contributor.authorCARIACO, YUSMARISpt_BR
dc.contributor.authorALMEIDA, MARCOS P.O.pt_BR
dc.contributor.authorMIRANDA, NATALIA C.pt_BR
dc.contributor.authorARAUJO, ESTER C.B.pt_BR
dc.contributor.authorSANTOS, SOFIA N. dospt_BR
dc.contributor.authorBERNARDES, EMERSON S.pt_BR
dc.contributor.authorSILVA, NEIDE M.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2022-12-19T15:11:18Z
dc.date.available2022-12-19T15:11:18Z
dc.date.issued2022pt_BR
dc.description.abstractNotch signaling pathway plays a crucial role in cellular fate across species, being important for the differentiation and development of several cell types. The aim of this study was to evaluate the effect of Notch inhibition pathway by dibenzazepine (DBZ) in histological and inflammatory alterations and, tissue parasitism in acute Toxoplasma gondii infection. For this, C57BL/6 mice were treated with DBZ before infection with T. gondii, and the small intestine, lungs and liver were analyzed. The genes related to Notch signaling pathway were assayed through qPCR in the organs, and cytokine measurement was performed in serum samples. In the small intestine, T. gondii infection impaired the Hes1 and Math1 mRNA expressions, increased the inflammation and decreased goblet and Paneth cell numbers. The DBZ-treatment was able to partially preserve these cells, however, the parasitism and inflammation were not altered. In parallel, the high IL-2, IL-6, TNF and, IFN-γ levels induced by infection were not changed with the DBZ treatment, with the IFN-γ levels even higher. In contrast, in the liver and lungs, the DBZ-treatment diminished parasitism and inflammation. Our results highlight that Notch pathway inhibition in T.gondii infection results in different parasitological and inflammatory outcomes depending on the organ analyzed.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipIDCAPES: 001pt_BR
dc.format.extent1-11pt_BR
dc.identifier.citationBRICENO, MARISOL P.; CARIACO, YUSMARIS; ALMEIDA, MARCOS P.O.; MIRANDA, NATALIA C.; ARAUJO, ESTER C.B.; SANTOS, SOFIA N. dos; BERNARDES, EMERSON S.; SILVA, NEIDE M. Effects of Notch signaling pathway inhibition by dibenzazepine in acute experimental toxoplasmosis. <b>Tissue and Cell</b>, v. 79, p. 1-11, 2022. DOI: <a href="https://dx.doi.org/10.1016/j.tice.2022.101952">10.1016/j.tice.2022.101952</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33477.
dc.identifier.doi10.1016/j.tice.2022.101952pt_BR
dc.identifier.issn0040-8166pt_BR
dc.identifier.orcid0000-0002-0029-7313pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0029-7313
dc.identifier.percentilfi51.4pt_BR
dc.identifier.percentilfiCiteScore27pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33477
dc.identifier.vol79pt_BR
dc.relation.ispartofTissue and Cellpt_BR
dc.rightsopenAccesspt_BR
dc.subjectzoonotic diseases
dc.subjectinfectious diseases
dc.subjectnotches
dc.subjectinhibition
dc.subjectorgans
dc.subjectdrugs
dc.subjectanimal cells
dc.subjectinflammation
dc.titleEffects of Notch signaling pathway inhibition by dibenzazepine in acute experimental toxoplasmosispt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorEMERSON SOARES BERNARDES
ipen.autorSOFIA NASCIMENTO DOS SANTOS
ipen.codigoautor12099
ipen.codigoautor14464
ipen.contributor.ipenauthorEMERSON SOARES BERNARDES
ipen.contributor.ipenauthorSOFIA NASCIMENTO DOS SANTOS
ipen.date.recebimento22-12
ipen.identifier.fi2.6pt_BR
ipen.identifier.fiCiteScore3.5pt_BR
ipen.identifier.ipendoc29111pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreArtigo
relation.isAuthorOfPublication8115c8bd-822c-4f5a-9f49-3c12570ed40a
relation.isAuthorOfPublicationab78881a-78eb-42be-a463-aaf80e70de3d
relation.isAuthorOfPublication.latestForDiscoveryab78881a-78eb-42be-a463-aaf80e70de3d
sigepi.autor.atividadeBERNARDES, EMERSON S.:12099:110:Npt_BR
sigepi.autor.atividadeSANTOS, SOFIA N. dos:14464:110:Npt_BR
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