Quantitative analysis of capillary non-perfusion in diabetic retinopathy using widefield OCT-angiography

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dc.contributor.authorALIBHAI, A.Y.
dc.contributor.authorPRETTO, LUCAS R. de
dc.contributor.authorMOULT, ERIC
dc.contributor.authorSCHOTTENHAMML, JULIA
dc.contributor.authorOR, CHRIS
dc.contributor.authorARYA, MALVIKA
dc.contributor.authorMCGOWAN, MITCHELL
dc.contributor.authorBAUMAL, CAROLINE
dc.contributor.authorWITKIN, ANDRE J.
dc.contributor.authorDUKER, JAY S.
dc.contributor.authorFUJIMOTO, JAMES G.
dc.contributor.authorWAHEED, NADIA K.
dc.coverageInternacionalpt_BR
dc.date.accessioned2019-04-11T14:04:49Z
dc.date.available2019-04-11T14:04:49Z
dc.date.issued2018pt_BR
dc.description.abstractPurpose : Several OCT angiography (OCTA) studies suggest an association between capillary non-perfusion, a surrogate for retinal ischemia, and diabetic retinopathy (DR) severity. However, due to technical limitations, these studies focused on either 3x3mm or 6x6mm fields of view centered on the macula. In contrast, widefield fluorescein angiography (FA) studies suggest that the majority of capillary non-perfusion in early DR occurs outside of the macular region. The recent development of high-speed, widefield OCTA systems, has for the first time allowed non-invasive visualization of retinal vasculature over wider fields of view—a functionality that, in light of previous widefield FA studies, may be promising for early detection and monitoring of DR. This study aims to couple the recent technological advances in high-speed, widefield OCTA with image processing methods to allow for semi-automatic quantitative analysis of capillary non-perfusion of widefield OCTA images of diabetic eyes. Methods : A semi-automatic, texture-based algorithm that detects areas of non-perfusion on 12x12mm SS-OCTA images from the Zeiss PlexElite™ system was developed. We tested the algorithm on a series of patients with diabetes without DR (28 eyes, 21 subjects; 54.8 ± 10.9 y/o), eyes with non-proliferative DR (NPDR) (24 eyes, 16 subjects; 62.1 ± 13.2 y/o) and eyes with proliferative DR (PDR) (21 eyes, 14 subjects; 52.2 ± 12.7 y/o). Results : There was a general trend of increasing capillary non-perfusion with increasing DR severity; however, there was significant overlap between patients having different DR severities (Fig. 1). Conclusions : Quantitative analysis of widefield OCTA images may be useful for early detection and monitoring for diabetic retinopathy progression in diabetics. Additional work is needed to determine the added value of widefield OCTA.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 16/17342-0pt_BR
dc.identifier.citationALIBHAI, A.Y.; PRETTO, LUCAS R. de; MOULT, ERIC; SCHOTTENHAMML, JULIA; OR, CHRIS; ARYA, MALVIKA; MCGOWAN, MITCHELL; BAUMAL, CAROLINE; WITKIN, ANDRE J.; DUKER, JAY S.; FUJIMOTO, JAMES G.; WAHEED, NADIA K. Quantitative analysis of capillary non-perfusion in diabetic retinopathy using widefield OCT-angiography. <b>Investigative Ophthalmology & Visual Science</b>, v. 59, n. 9, 2018. Disponível em: http://repositorio.ipen.br/handle/123456789/29843.
dc.identifier.fasciculo9pt_BR
dc.identifier.issn0146-0404pt_BR
dc.identifier.orcidaguardandopt_BR
dc.identifier.percentilfi85.593pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29843
dc.identifier.vol59pt_BR
dc.relation.ispartofInvestigative Ophthalmology & Visual Sciencept_BR
dc.rightsopenAccesspt_BR
dc.sourceAnnual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, APR 29-MAY 03, 2018pt_BR
dc.subjectretina
dc.subjectdiabetes mellitus
dc.subjectperfused organs
dc.subjectfluorescein
dc.subjectbiomedical radiography
dc.titleQuantitative analysis of capillary non-perfusion in diabetic retinopathy using widefield OCT-angiographypt_BR
dc.typeResumos em periódicospt_BR
dspace.entity.typePublication
ipen.autorLUCAS RAMOS DE PRETTO
ipen.codigoautor11268
ipen.contributor.ipenauthorLUCAS RAMOS DE PRETTO
ipen.date.recebimento19-04pt_BR
ipen.identifier.fi3.388pt_BR
ipen.identifier.ipendoc25645pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi75.00 - 100.00
ipen.type.genreResumo
relation.isAuthorOfPublication64a32d36-2971-45c5-a8a3-c266b2ed3e42
relation.isAuthorOfPublication.latestForDiscovery64a32d36-2971-45c5-a8a3-c266b2ed3e42
sigepi.autor.atividadePRETTO, LUCAS R. DE:11268:920:Npt_BR
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