Development of lignin-PVP based dressing for wound treatment

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dc.contributor.authorNOGUEIRA, K.M.
dc.contributor.authorVARCA, J.O.
dc.contributor.authorVARCA, G.H.C.
dc.contributor.authorLIMA, C.S.A.
dc.contributor.authorLUGAO, A.B.
dc.coverageNacionalpt_BR
dc.creator.eventoCONGRESSO BRASILEIRO DE ENGENHARIA E CIÊNCIA DOS MATERIAIS, 23.pt_BR
dc.date.accessioned2019-02-20T12:52:14Z
dc.date.available2019-02-20T12:52:14Z
dc.date.evento04-08 de novembro, 2018pt_BR
dc.description.abstractLignin is a carbon renewable source and has been widely explored in different fields in the last years, especially in biomaterials as dressing and other biomedical devices due its natural origin and low cost1. Poly(ethylene oxide) (PEO) is a synthetic polymer largely used in biomedical applications due its important characteristics such as high hydrophilicity, non-toxicity and ease of process2. The present work aimed to develop a lignin-PEO based dressing for wound treatment by casting. In specific terms, three different polymer blends were formulated using a range of 3 to 10% (w/v) lignin was tested with the addition of 1 to 3% PEO. Lignin was solubilized in aqueous solution (pH>13) alkalized with sodium hydroxide and PEO was solubilized in distilled water. The solutions were heated up to 70 ºC and homogenized until complete polymer dissolution. Then, PEO solution and poly(ethylene glycol) diacrylate (PEGDA) (0.5 - 1.0%) were added to the lignin solution and the blend was mixed for 30 minutes at 70 ºC. Posteriorly the blends were submitted to casting and drying under different conditions, room temperature for 48 hours and incubated at 40 ºC for 24 hours. A control sample of 6% lignin was prepared in the same conditions. Samples were evaluated by physico-chemical and morphological characterizations. The swelling and gel fraction profiles were assessed as well as thermal behavior by differential scanning calorimetry. Chemical modifications were evaluated by infrared spectroscopy. Samples with higher PEGDA content presented minor swelling index. The blends formulated presented different thermal behavior in comparison with the control. Infrared spectroscopy pointed some chemical modifications promoted by the crosslinking agent. In general terms, the material developed presented a potential to continue been explored as dressing for wound treatmentpt_BR
dc.event.siglaCBECiMatpt_BR
dc.format.extent7289-7289pt_BR
dc.identifier.citationNOGUEIRA, K.M.; VARCA, J.O.; VARCA, G.H.C.; LIMA, C.S.A.; LUGAO, A.B. Development of lignin-PVP based dressing for wound treatment. In: CONGRESSO BRASILEIRO DE ENGENHARIA E CIÊNCIA DOS MATERIAIS, 23., 04-08 de novembro, 2018, Foz do Iguaçu, PR. <b>Resumo...</b> p. 7289-7289. Disponível em: http://repositorio.ipen.br/handle/123456789/29660.
dc.identifier.orcidaguardandopt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29660
dc.local.eventoFoz do Iguaçu, PRpt_BR
dc.rightsopenAccesspt_BR
dc.subjectbiological materials
dc.subjectlignin
dc.subjectinfrared spectra
dc.subjectpolymers
dc.subjectrenewable resources
dc.subjectwounds
dc.subjecttherapy
dc.subjecthealing
dc.titleDevelopment of lignin-PVP based dressing for wound treatmentpt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.autorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.codigoautor339
ipen.codigoautor8661
ipen.codigoautor8726
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.contributor.ipenauthorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.date.recebimento19-02pt_BR
ipen.event.datapadronizada2018pt_BR
ipen.identifier.ipendoc25412pt_BR
ipen.notas.internasResumopt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
relation.isAuthorOfPublication46f998cf-b207-4854-94c0-dd2def4eec2a
relation.isAuthorOfPublicatione31cd2b4-ae29-47a5-aa35-ba3e58cdeb92
relation.isAuthorOfPublication.latestForDiscoverye31cd2b4-ae29-47a5-aa35-ba3e58cdeb92
sigepi.autor.atividadeVARCA, J.O.:8726:740:Spt_BR
sigepi.autor.atividadeVARCA, G.H.C.:8661:750:Npt_BR
sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
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