Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation

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dc.contributor.authorVIEIRA, D.P.
dc.contributor.authorGALISTEO JUNIOR, A.J.
dc.contributor.authorANDRADE JUNIOR, H.F. de
dc.coverageNacionalpt_BR
dc.date.accessioned2019-03-01T11:41:38Z
dc.date.available2019-03-01T11:41:38Z
dc.date.issued2019pt_BR
dc.description.abstractReduction of nitric oxide (NO) production is related to increased survival in some models of infection and ionizing radiation (IR) exposure. The work used lethally irradiated (60Co, 8Gy) C57Bl6j mice, treated or not with aminoguanidine (AG), an inhibitor of an isoform of nitric oxide synthase (iNOS). Also tested iNOS-/- knockout mice and a distinct group treated intraperitoneally with synthetic CXCL12, a homing chemokine related to hematopoietic reconstitution after IR exposures. Aminoguanidine treatment lead to an overshoot of proliferation of hematopoietic CD34+ cells in bone marrows (day 2 after IR) and spleens (days 2 and 4 after IR) of irradiated mice, showing a compensative response of these organs against deleterious effects of radiation. CXCL12 mRNA production was increased on spleens of AG-treated mice at day 2 after IR, but not on other periods neither in bone marrows. CXCL12 administration did not alter CD34+ counts but seemed to keep circulating platelet counts in levels comparable to controls. Thus, CXCL12 and AG administration could help on bone marrow repopulation after critically exposed individuals.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipIDCNPq: 141113/2002-2; 470873/2004-3pt_BR
dc.format.extent1-24pt_BR
dc.identifier.citationVIEIRA, D.P.; GALISTEO JUNIOR, A.J.; ANDRADE JUNIOR, H.F. de. Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation. <b>Brazilian Journal of Radiation Sciences</b>, v. 07, n. 01, p. 1-24, 2019. DOI: <a href="https://dx.doi.org/10.15392/bjrs.v7i1.789">10.15392/bjrs.v7i1.789</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/29742.
dc.identifier.doi10.15392/bjrs.v7i1.789pt_BR
dc.identifier.fasciculo01pt_BR
dc.identifier.issn2319-0612pt_BR
dc.identifier.orcidaguardandopt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0007-534X
dc.identifier.percentilfiSem Percentilpt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29742
dc.identifier.vol07pt_BR
dc.relation.ispartofBrazilian Journal of Radiation Sciencespt_BR
dc.rightsopenAccesspt_BR
dc.subjectnitric oxide
dc.subjectblood formation
dc.subjectlaboratories
dc.subjectgamma radiation
dc.subjectbioassay
dc.subjectmice
dc.subjectguanidines
dc.subjectcobalt 60
dc.subjectspleen
dc.subjectbiological radiation effects
dc.subjectlethal doses
dc.titleInhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiationpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorDANIEL PEREZ VIEIRA
ipen.codigoautor3158
ipen.contributor.ipenauthorDANIEL PEREZ VIEIRA
ipen.date.recebimento19-03pt_BR
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.ipendoc25522pt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationc2352608-be9c-4a73-be8c-571f10bb53d2
relation.isAuthorOfPublication.latestForDiscoveryc2352608-be9c-4a73-be8c-571f10bb53d2
sigepi.autor.atividadeVIEIRA, D.P.:3158:810:Spt_BR
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