Synthesis and characterization of hydrogels loaded neomycin for infection topic treatment and veterinary use

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dc.contributor.advisorDuclerc Fernandes Parrapt_BR
dc.contributor.authorZAFALON, ANGELICA T.
dc.coverageNacionalpt_BR
dc.date.accessioned2019-04-04T17:55:42Z
dc.date.available2019-04-04T17:55:42Z
dc.date.issued2018pt_BR
dc.description.abstractHydrogels are natural or synthetic polymer systems that have been vastly applied in the pharmaceutical industry due to their high soft tissue biocompatibility. These hydrogels have been used in dressings as a controlled drug release system. In this study, hydrogels were prepared using poly (N-vinyl-2-pyrrolidone) (PVP), poly (ethylene glycol) (PEG), agar and neomycin followed by gamma irradiation to promote crosslinking and sterilization. The influence of the irradiation process at 25 kGy dose was investigated. The gel fraction and maximum swelling were estimated using physicochemical methods and found about 95% gel fraction and 1100% swelling after 8 hours of immersion. Neomycin released from the hydrogel was measured by the Liquid Chromatography-Mass Spectrometry method and the drug concentration remained constant for 48 hours. Hydrogel / neomycin exhibited antibacterial effect against bacteria and biofilm of Pseudomonas aeruginosa and Staphylococcus aureus. The hydrogel was used in the treatment of pododermatitis in penguins healing process without signs of contamination. With these results, it can be inferred that the hydrogel / neomycin is a suitable candidate for wound dressings.pt_BR
dc.description.notasgeraisTese (Doutorado em Tecnologia Nuclear)pt_BR
dc.description.notasteseIPEN/Tpt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCAPES: 88881.134341/2016-01
dc.description.teseinstituicaoInstituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SPpt_BR
dc.format.extent95pt_BR
dc.identifier.citationZAFALON, ANGELICA T. <b>Synthesis and characterization of hydrogels loaded neomycin for infection topic treatment and veterinary use</b>. Orientador: Duclerc Fernandes Parra. 2018. 95 f. Tese (Doutorado em Tecnologia Nuclear) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. DOI: <a href="https://dx.doi.org/10.11606/T.85.2020.tde-08112018-113736">10.11606/T.85.2020.tde-08112018-113736</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/29836.
dc.identifier.doi10.11606/T.85.2020.tde-08112018-113736
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29836
dc.localSão Paulopt_BR
dc.rightsopenAccesspt_BR
dc.subjecthydrogels
dc.subjectsynthesis
dc.subjectneomycin
dc.subjectdrugs
dc.subjectantimicrobial agentes
dc.subjectdermatitis
dc.subjectradiotherapy
dc.subjectaquatic organisms
dc.subjectbirds
dc.subjectgamma radiation
dc.subjectveterinary medicine
dc.titleSynthesis and characterization of hydrogels loaded neomycin for infection topic treatment and veterinary usept_BR
dc.title.alternativeSíntese e caracterização de hidrogéis com neomicina para tratamento de infecções tópicas e uso veterináriopt_BR
dc.typeTesept_BR
dspace.entity.typePublication
ipen.autorANGELICA TAMIÃO ZAFALON
ipen.codigoautor6419
ipen.contributor.ipenauthorANGELICA TAMIÃO ZAFALON
ipen.date.recebimento19-04pt_BR
ipen.identifier.ipendoc25615pt_BR
ipen.meioeletronicohttps://teses.usp.br/teses/disponiveis/85/85134/tde-08112018-113736/pt-br.php
ipen.type.genreTese
relation.isAuthorOfPublication49d823d7-3167-4065-8db0-9ed6915062cc
relation.isAuthorOfPublication.latestForDiscovery49d823d7-3167-4065-8db0-9ed6915062cc
sigepi.autor.atividadeZAFALON, ANGELICA T.:6419:740:Spt_BR
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