Periodontal treatment combined to antimicrobial photodynamic therapy

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dc.contributor.authorGODOY-MIRANDA, BIANCA
dc.contributor.authorBELINELLO-SOUZA, ESTEFANI
dc.contributor.authorALVARENGA, LETICIA
dc.contributor.authorLEAL, CINTIA
dc.contributor.authorLEITE, CAROLINA
dc.contributor.authorLIMA, TAIRINE
dc.contributor.authorPREVIATI-OLIVEIRA, JHOSEPHER
dc.contributor.authorFREITAS, ANDERSON
dc.contributor.authorPRETTO, LUCAS de
dc.contributor.authorFERNANDES, ADJACI
dc.contributor.authorPRATES, RENATO
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-03-26T17:26:47Z
dc.date.available2018-03-26T17:26:47Z
dc.date.issued2017pt_BR
dc.description.abstractBackground: Antimicrobial photodynamic therapy (APDT) has been used as an adjuvant treatment for periodontitis. It combines a photosensitizer (PS) with a light source to induce reactive oxygen species (ROS) and kill microbial cells. PpNetNI is a protoporphyrin derivate, and it has a chemical binding site at biofilm and great affinity to microbial cells. The aim of this study was to investigate the effects of APDT as an adjuvant treatment for periodontitis. Study: Ten healthy male rats Wistar (Rattus norvegicus) were used in this study (Approved by UNINOVE Ethical committee AN0029/2015). Periodontitis was induced by placing a cotton ligature around the first mandibular molar in a subgingival position. The contralateral mandibular first molar received neither a ligature nor any treatment, and was used as a control. After 7 days, the ligature was removed and all animals received scaling and root planning (SRP) and were divided according to the following treatments: SRP group (received SRP and irrigation with PpNetNI, 10 mM) and PDT group (PpNetNI 10 mM followed by LED irradiation). PDT was performed with a LED (630 nm) with an output power of 400mW (fluence-rate 200mW/cm2; fluence 18 J/cm2). Rats were euthanized at 7 days postoperatively. The bone loss was measured by Optical Coherence Tomography (OCT, THORLABS LTD., Newton, US). Data were analyzed statistically (Mann-Whitney test, p<0.05). in vestibular region of the first molar Results: The animals treated by APDT showed a bone gain of approximately 30% compared to the SRP group following 7 days from the treatment. OCT was able to detect bone loss in the samples and it was nondestructive method for this experimental model. Conclusion: In conclusion, within the parameters used in this study, APDT was an effective alternative to held periodontal health after treatment, and it was able to regenerate supportive periodontal tissue.pt_BR
dc.format.extent42-43pt_BR
dc.identifier.citationGODOY-MIRANDA, BIANCA; BELINELLO-SOUZA, ESTEFANI; ALVARENGA, LETICIA; LEAL, CINTIA; LEITE, CAROLINA; LIMA, TAIRINE; PREVIATI-OLIVEIRA, JHOSEPHER; FREITAS, ANDERSON; PRETTO, LUCAS de; FERNANDES, ADJACI; PRATES, RENATO. Periodontal treatment combined to antimicrobial photodynamic therapy: experimental model. <b>Lasers in Surgery and Medicine</b>, v. 49, n. S28, p. 42-43, 2017. DOI: <a href="https://dx.doi.org/10.1002/lsm.22650">10.1002/lsm.22650</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28802.
dc.identifier.doi10.1002/lsm.22650pt_BR
dc.identifier.fasciculoS28pt_BR
dc.identifier.issn0196-8092pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5018-9126
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28802
dc.identifier.vol49pt_BR
dc.relation.ispartofLasers in Surgery and Medicinept_BR
dc.rightsopenAccesspt_BR
dc.subjectexperimental data
dc.subjectantimicrobial agents
dc.subjectphotosensitivity
dc.subjectdentistry
dc.subjectbone cells
dc.subjectdiagnostic techniques
dc.titlePeriodontal treatment combined to antimicrobial photodynamic therapypt_BR
dc.typeResumos em periódicospt_BR
dspace.entity.typePublication
ipen.autorRENATO ARAÚJO PRATES
ipen.autorLUCAS RAMOS DE PRETTO
ipen.autorANDERSON ZANARDI DE FREITAS
ipen.codigoautor4028
ipen.codigoautor11268
ipen.codigoautor880
ipen.contributor.ipenauthorRENATO ARAÚJO PRATES
ipen.contributor.ipenauthorLUCAS RAMOS DE PRETTO
ipen.contributor.ipenauthorANDERSON ZANARDI DE FREITAS
ipen.date.recebimento18-03pt_BR
ipen.identifier.fi2.312pt_BR
ipen.identifier.ipendoc22998pt_BR
ipen.range.fi1.500 - 2.999
ipen.subtituloexperimental modelpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublicationfde20222-8ca2-4a9e-941b-516590cac130
relation.isAuthorOfPublication64a32d36-2971-45c5-a8a3-c266b2ed3e42
relation.isAuthorOfPublicationa8d821f0-a0a4-4d52-b582-5c5d0afce8f5
relation.isAuthorOfPublication.latestForDiscoverya8d821f0-a0a4-4d52-b582-5c5d0afce8f5
sigepi.autor.atividadeFREITAS, ANDERSON:880:920:Npt_BR
sigepi.autor.atividadePRETTO, LUCAS DE:11268:920:Npt_BR
sigepi.autor.atividadePRATES, RENATO:4028:920:Npt_BR
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