Degradation and toxicity of amoxicillin after electron beam irradiation

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dc.contributor.authorBORRELY, S.I.pt_BR
dc.contributor.authorREDÍGOLO, M.M.pt_BR
dc.contributor.authorVILLARD, B.D.pt_BR
dc.contributor.authorLEBRE, D.T.pt_BR
dc.contributor.authorTOMINAGA, F.K.pt_BR
dc.coverageNacionalpt_BR
dc.date.accessioned2022-12-20T14:23:51Z
dc.date.available2022-12-20T14:23:51Z
dc.date.issued2022pt_BR
dc.description.abstractA recent and growing concern in environmental studies is the presence of antibiotics in wastewater, which contributes to antimicrobial resistance building. Amoxicillin, according to the World Health Organization, is one of the most consumed antibiotics worldwide, for being a first line therapy for common infections. Among several drug degradation methodologies, electron beam irradiation (EBI) is presented as an efficient and green treatment. This work presents data on amoxicillin degradation via EBI. Degradation rate was evaluated by LC/MS-MS, carbon removal efficiency was evaluated by TOC and ecotoxicity assays were performed employing Vibrio fischeri. Chromatographic results indicate an efficiency removal of 97.65% at 0.75 kGy and concentration below the limit of detection with increasing absorbed dose. Low mineralization (up to 10%) was achieved at 3.0 kGy. Regarding toxicity, approximately 81% of toxicity removal was obtained at 0.75 kGy and a decrease in efficiency was achieved with higher doses. In conclusion, results indicate the low doses (0.75 kGy) as most effective for drug removal employing EBI.pt_BR
dc.format.extent1-8pt_BR
dc.identifier.citationBORRELY, S.I.; REDÍGOLO, M.M.; VILLARD, B.D.; LEBRE, D.T.; TOMINAGA, F.K. Degradation and toxicity of amoxicillin after electron beam irradiation. <b>Brazilian Journal of Radiation Sciences</b>, v. 10, n. 3B, p. 1-8, 2022. DOI: <a href="https://dx.doi.org/10.15392/2319-0612.2022.1894">10.15392/2319-0612.2022.1894</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33499.
dc.identifier.doi10.15392/2319-0612.2022.1894pt_BR
dc.identifier.fasciculo3Bpt_BR
dc.identifier.issn2319-0612pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9692-5539
dc.identifier.percentilfiSem Percentilpt_BR
dc.identifier.percentilfiCiteScoreSem Percentil CiteScorept_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33499
dc.identifier.vol10pt_BR
dc.relation.ispartofBrazilian Journal of Radiation Sciencespt_BR
dc.rightsopenAccesspt_BR
dc.sourceMeeting on Nuclear Applications (ENAN), 15th, November 29 - December 2, 2021, Onlinept_BR
dc.subjectantibiotics
dc.subjectwaste water
dc.subjectwater pollution
dc.subjecttoxicity
dc.subjectdecomposition
dc.subjectdetoxification
dc.subjectelectron beams
dc.subjectionizing radiations
dc.subjectirradiation
dc.titleDegradation and toxicity of amoxicillin after electron beam irradiationpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMARCELO MIYADA REDÍGOLO
ipen.autorFLAVIO KIYOSHI TOMINAGA
ipen.autorDANIEL TEMPONI LEBRE
ipen.autorBRUNO DAVID QUIROZ VILLARDI
ipen.autorSUELI IVONE BORRELY
ipen.codigoautor5976
ipen.codigoautor12754
ipen.codigoautor2053
ipen.codigoautor15162
ipen.codigoautor150
ipen.contributor.ipenauthorMARCELO MIYADA REDÍGOLO
ipen.contributor.ipenauthorFLAVIO KIYOSHI TOMINAGA
ipen.contributor.ipenauthorDANIEL TEMPONI LEBRE
ipen.contributor.ipenauthorBRUNO DAVID QUIROZ VILLARDI
ipen.contributor.ipenauthorSUELI IVONE BORRELY
ipen.date.recebimento22-12
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.fiCiteScoreSem CiteScorept_BR
ipen.identifier.ipendoc29133pt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationccb89a44-c80a-4c9b-8620-b2f958f9b2c6
relation.isAuthorOfPublicationaa4a15b8-4ad7-4bb6-a280-c0de5cf947d6
relation.isAuthorOfPublicationb1305c93-be39-477e-97ae-bd94c730015d
relation.isAuthorOfPublication237dc736-71d7-4f18-8389-163305524359
relation.isAuthorOfPublication76171e20-c8ac-475f-9006-27402113c92f
relation.isAuthorOfPublication.latestForDiscovery76171e20-c8ac-475f-9006-27402113c92f
sigepi.autor.atividadeTOMINAGA, F.K.:12754:220:Npt_BR
sigepi.autor.atividadeLEBRE, D.T.:2053:520:Npt_BR
sigepi.autor.atividadeVILLARD, B.D.:15162:610:Npt_BR
sigepi.autor.atividadeREDÍGOLO, M.M.:5976:730:Npt_BR
sigepi.autor.atividadeBORRELY, S.I.:150:220:Spt_BR
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