Cytotoxic activity and chemical profile of methanolic extract obtained from Avelós stem (Euphorbia tirucalli L.) Euphorbiaceae

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dc.contributor.authorRUSSO, DANIELA C.pt_BR
dc.contributor.authorAMARAL, KLEICY C.pt_BR
dc.contributor.authorCALDAS, LHAIS A.pt_BR
dc.contributor.authorVIEIRA, DANIEL P.pt_BR
dc.contributor.authorSARTORELLI, PATRICIApt_BR
dc.contributor.authorRIBEIRO FILHO, WALDEMAR A.pt_BR
dc.coverageNacionalpt_BR
dc.creator.eventoREUNIÃO ANUAL VIRTUAL DA SBQ, 43.pt_BR
dc.date.accessioned2020-12-21T18:11:43Z
dc.date.available2020-12-21T18:11:43Z
dc.date.evento5-16 de outubro, 2020pt_BR
dc.description.abstractAvelós (Euphorbia tirucalli Linnaeus), a plant selected for this study, has been popularly used in the fight against tumors, arousing the interest of researchers in this area so that it can be used safely in the auxiliary treatment of different types of cancer.1 It belongs to the family Euphorbiaceae and to the genus Euphorbia, it is also the object of studies related to the treatment of a range of infectious and inflammatory diseases. Herbaceous much used by popular and traditional medicine, presents, a latex rich in molecules that confirm its high toxicity. The objective of this research was to verify the chemical profile of the metanolic extract obtained from the stem (modified leaves) of the plant in question and to determine the cytotoxicity of the crude extract by cytotoxic assay against the lineages of adenocarcinoma (MCF-7) and neoplastic cells of human melanoma (SK-MEL-37).2 For this, the plant was collected, and after drying and milling the material was extracted with methanol. Subsequently, the present compounds were separated by the thin-layer chromatography technique and the classes of substances found in the extract were identified by the technique of Nuclear Magnetic Resonance of Hydrogen and Carbon-13 (NMR).3 The combination of cyclohexane with Acetone and Hexane (5: 3: 2) provided a suitable polarity for the elution of the extract, which was revealed with ultraviolet detection and different reagents: sulfuric acid solutions; aluminum chloride; ferric chloride; 10% potassium hydroxide in ethanol; green bromocresol indicator solution; potassium permanganate, Dragendorff Reagent, vanillin and iodine vapors. The phytochemical study of the methanolic extract of Euphorbia tirucalli allowed to identify the presence of phenolic compounds, flavonoids and terpenes, a result that was confirmed by NMR spectra. The cytotoxic potential assays, although they are in low concentration thus altering the result, show that the methanolic extract of Euphorbia tirucalli shows activity against the tested cell lines. The observed activity may be related, according to information available in the literature, with the classes identified in the samples studied.pt_BR
dc.event.siglaRASBQpt_BR
dc.identifier.citationRUSSO, DANIELA C.; AMARAL, KLEICY C.; CALDAS, LHAIS A.; VIEIRA, DANIEL P.; SARTORELLI, PATRICIA; RIBEIRO FILHO, WALDEMAR A. Cytotoxic activity and chemical profile of methanolic extract obtained from Avelós stem (Euphorbia tirucalli L.) Euphorbiaceae. In: REUNIÃO ANUAL VIRTUAL DA SBQ, 43., 5-16 de outubro, 2020, Virtual. <b>Resumo...</b> Campinas: Galoá, 2020. Disponível em: http://200.136.52.105/handle/123456789/31697.
dc.identifier.orcid0000-0002-0007-534Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0007-534X
dc.identifier.urihttp://200.136.52.105/handle/123456789/31697
dc.localCampinaspt_BR
dc.local.eventoVirtualpt_BR
dc.publisherGaloápt_BR
dc.rightsopenAccesspt_BR
dc.titleCytotoxic activity and chemical profile of methanolic extract obtained from Avelós stem (Euphorbia tirucalli L.) Euphorbiaceaept_BR
dc.title.alternativeAtividade citotóxica e perfil químico do extrato metanólico obtido do caule de Avelós (Euphorbia tirucalli L.) Euphorbiaceaept_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorDANIEL PEREZ VIEIRA
ipen.autorKLEICY CAVALCANTE AMARAL
ipen.codigoautor3158
ipen.codigoautor14186
ipen.contributor.ipenauthorDANIEL PEREZ VIEIRA
ipen.contributor.ipenauthorKLEICY CAVALCANTE AMARAL
ipen.date.recebimento20-12
ipen.event.datapadronizada2020pt_BR
ipen.identifier.ipendoc27469pt_BR
ipen.notas.internasResumopt_BR
ipen.type.genreResumo
relation.isAuthorOfPublicationc2352608-be9c-4a73-be8c-571f10bb53d2
relation.isAuthorOfPublicationfa441f6c-f316-4ff3-a5e8-33a613958188
relation.isAuthorOfPublication.latestForDiscoveryfa441f6c-f316-4ff3-a5e8-33a613958188
sigepi.autor.atividadeVIEIRA, DANIEL P.:3158:810:Npt_BR
sigepi.autor.atividadeAMARAL, KLEICY C.:14186:810:Npt_BR
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