Ames test to detect mutagenicity of 2-alkylcyclobutanones: a review

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dc.contributor.authorBARBEZAN, ANGELICA B.
dc.contributor.authorMARTINS, REGIANE
dc.contributor.authorBUENO, JENNIFER B.
dc.contributor.authorVILLAVICENCIO, ANNA L.C.H.
dc.coverageInternacionalpt_BR
dc.date.accessioned2017-07-03T17:19:49Z
dc.date.available2017-07-03T17:19:49Z
dc.date.issued2017pt_BR
dc.description.abstractFood irradiation is an effective and safe method for preservation and long-term storage, and it is approved for use in over 60 countries for various applications in a wide variety of food products. This process is performed by use of accelerated electron beams, X-rays, or gamma radiation (60Co or 137Cs). 2-Alkylcyclobutanones (2-ACBs) are the only known radiolytic products generated from foods that have fatty acids (triglycerides) and are subjected to irradiation. Since the 1990s toxicological safety studies of 2-ACBs have been conducted extensively through synthetic compounds, then and tests to determine if the compounds have any mutagenic activity are strictly necessary. The Ames test was chosen by many researchers to assess the mutagenicity of 2-ACBs. The test uses distinct bacterial cell lines Salmonella typhimurium to detect point mutations at sites guanine–cytosine (G–C) and Escherichia coli to detect point mutations at sites adenine–thymine (A–T). This bibliographic research aims to bring together all the results obtained and a comparison and cell lines used, type of plates, and solvents. This research showed that no mutagenic activity was observed in any of the cell lines and concentrations evaluated by the works of authors, so the 2-ACBs compounds showed no mutagenic substance in concentrations detectable by the Ames test.pt_BR
dc.format.extent1-5pt_BR
dc.identifier.citationBARBEZAN, ANGELICA B.; MARTINS, REGIANE; BUENO, JENNIFER B.; VILLAVICENCIO, ANNA L.C.H. Ames test to detect mutagenicity of 2-alkylcyclobutanones: a review. <b>Journal of Food Science</b>, v. 00, n. 0, p. 1-5, 2017. DOI: <a href="https://dx.doi.org/10.1111/1750-3841.13721">10.1111/1750-3841.13721</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/27595.
dc.identifier.doi10.1111/1750-3841.13721pt_BR
dc.identifier.fasciculo0pt_BR
dc.identifier.issn0022-1147pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6199-7877
dc.identifier.percentilfi59.77en
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/27595
dc.identifier.vol00pt_BR
dc.relation.ispartofJournal of Food Sciencept_BR
dc.rightsclosedAccesspt_BR
dc.subjectfood processing
dc.subjectirradiation
dc.subjectmutagenesis
dc.subjectmutations
dc.subjectbutanols
dc.subjectcycloalkanes
dc.subjecttesting
dc.subjectamericium
dc.titleAmes test to detect mutagenicity of 2-alkylcyclobutanones: a reviewpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorREGIANE MARTINS
ipen.autorJENNIFER BRUNA BUENO
ipen.autorANNA LUCIA CASANAS HAASIS VILLAVICENCIO
ipen.autorANGELICA BUENO BARBEZAN
ipen.codigoautor14027
ipen.codigoautor14262
ipen.codigoautor1372
ipen.codigoautor6417
ipen.contributor.ipenauthorREGIANE MARTINS
ipen.contributor.ipenauthorJENNIFER BRUNA BUENO
ipen.contributor.ipenauthorANNA LUCIA CASANAS HAASIS VILLAVICENCIO
ipen.contributor.ipenauthorANGELICA BUENO BARBEZAN
ipen.date.recebimento17-07pt_BR
ipen.identifier.fi2.018pt_BR
ipen.identifier.ipendoc23831pt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreArtigo
relation.isAuthorOfPublicationad3692a6-2f6b-4b47-9284-c6eee5d2084d
relation.isAuthorOfPublication9764f08d-8f7b-4bd8-9d0d-48ca4806e8bf
relation.isAuthorOfPublication8ce58b2f-23cf-45b5-a8c4-0fb067965096
relation.isAuthorOfPublication27082032-b0c8-462c-8d6c-767873119adf
relation.isAuthorOfPublication.latestForDiscovery27082032-b0c8-462c-8d6c-767873119adf
sigepi.autor.atividadeBARBEZAN, ANGELICA B.:6417:210:Spt_BR
sigepi.autor.atividadeMARTINS, REGIANE:14027:210:Npt_BR
sigepi.autor.atividadeBUENO, JENNIFER B.:14262:210:Npt_BR
sigepi.autor.atividadeVILLAVICENCIO, ANNA L.C.H.:1372:210:Npt_BR
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