The effect of GO-PEG-NH2 on the mechanical resistance of bovine pericardium used in cardiovascular device

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dc.contributor.authorSOARES, JAQUELINE J.S.
dc.contributor.authorJACOVONE, RAYNARA M.S.
dc.contributor.authorMATHOR, MONICA B.
dc.contributor.authorZAIM, MARCIO H.
dc.contributor.authorMAIZATO, MARINA J.S.
dc.contributor.authorCESTARI, IDAGENE A.
dc.contributor.authorJATENE, FABIO B.
dc.contributor.authorSAKATA, SOLANGE K.
dc.coverageInternacionalpt_BR
dc.creator.eventoPAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1stpt_BR
dc.date.accessioned2018-08-14T11:19:48Z
dc.date.available2018-08-14T11:19:48Z
dc.date.evento27-30 de novembro, 2017pt_BR
dc.description.abstractValvular heart disease (VHD) is a clinical condition where one of the four-heart valves is damage or has a defect. It was estimated that approximately 300,000 to 400,000 heart valve replacement surgeries were performed in 2014. There are two types of prostheses, the bioprothesis and the mechanical prosthesis. Even though the first one presents a smaller rejection, its durability is reduced due to calcification followed by deterioration. The objective of this work was to increase the durability of prostheses made from bovine pericardium (BP) by incorporating GO functionalized with amino-PEG (GO-PEG-NH2). Briefly, GO functionalized was firstly sterilized with gamma radiation and then incorporated to BP in two different ways: chemical and physical. Mechanical characterization assays of BP treated with GO-PEG-NH2 and untreated (control) were performed in an INSTRON model 3365 universal test equipment using the BioPlus accessory, which allows the assays to be carried out immersed in a physiological solution of 0,9% NaCl at 36 °C, simulating the environment of material’s application. The static deformation in the uniaxial direction of the test specimens was verified using the ASTM D638-10 standard test method for tensile properties of plastics, 2010 from the American Society for Testing and Materials (ASTM Standards). The results indicated that GO-PEG-NH2 improved the mechanical strength of the biomaterial, increasing the resistance to permanent plastic deformation, maximum supported load, flow limit, maximum traction tension, rupture tenacity and rupture traction tension no matter of GO-PEG-NH2 incorporation methods and it is possible to improve the performance of bioprothesis by coating them with GO-PEG-NH2 and consequently increasing their durability.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 17/20177-3pt_BR
dc.event.siglaPANNANOpt_BR
dc.identifier.citationSOARES, JAQUELINE J.S.; JACOVONE, RAYNARA M.S.; MATHOR, MONICA B.; ZAIM, MARCIO H.; MAIZATO, MARINA J.S.; CESTARI, IDAGENE A.; JATENE, FABIO B.; SAKATA, SOLANGE K. The effect of GO-PEG-NH2 on the mechanical resistance of bovine pericardium used in cardiovascular device. In: PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1st, 27-30 de novembro, 2017, Guarujá, SP. <b>Abstract...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/29058.
dc.identifier.orcidhttps://orcid.org/0000-0001-6072-5853
dc.identifier.orcidhttp://orcid.org/0000-0002-7294-9106
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29058
dc.local.eventoGuarujá, SPpt_BR
dc.rightsopenAccesspt_BR
dc.titleThe effect of GO-PEG-NH2 on the mechanical resistance of bovine pericardium used in cardiovascular devicept_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorSOLANGE KAZUMI SAKATA
ipen.autorMONICA BEATRIZ MATHOR
ipen.autorRAYNARA MARIA SILVA JACOVONE
ipen.autorJAQUELINE JAMARA SOUZA SOARES
ipen.codigoautor7038
ipen.codigoautor209
ipen.codigoautor14300
ipen.codigoautor14313
ipen.contributor.ipenauthorSOLANGE KAZUMI SAKATA
ipen.contributor.ipenauthorMONICA BEATRIZ MATHOR
ipen.contributor.ipenauthorRAYNARA MARIA SILVA JACOVONE
ipen.contributor.ipenauthorJAQUELINE JAMARA SOUZA SOARES
ipen.date.recebimento18-08pt_BR
ipen.event.datapadronizada2017pt_BR
ipen.identifier.ipendoc24850pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublicationfb62f288-104d-4352-aed0-a18e0da21a1b
relation.isAuthorOfPublication742b424f-9dfb-4e4a-993b-000052bb1313
relation.isAuthorOfPublicationda20f0e7-9926-4e06-ae80-ccbc18ec0806
relation.isAuthorOfPublicationcd8afcda-d573-47ce-baa2-ad03bf07b780
relation.isAuthorOfPublication.latestForDiscoverycd8afcda-d573-47ce-baa2-ad03bf07b780
sigepi.autor.atividadeSOARES, JAQUELINE J.S.:14313:220:Spt_BR
sigepi.autor.atividadeJACOVONE, RAYNARA M.S.:14300:220:Npt_BR
sigepi.autor.atividadeMATHOR, MONICA B.:209:240:Npt_BR
sigepi.autor.atividadeSAKATA, SOLANGE K.:7038:220:Npt_BR
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