Anti-HER2 monoclonal antibody based-radioimmunoconjugates

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dc.contributor.authorMIRANDA, ANA C.C.pt_BR
dc.contributor.authorDURANTE, ANA C.R.pt_BR
dc.contributor.authorFUSCALDI, LEONARDO L.pt_BR
dc.contributor.authorBARBEZAN, ANGELICA B.pt_BR
dc.contributor.authorLIMA, CILENE R. dept_BR
dc.contributor.authorPERINI, EFRAINpt_BR
dc.contributor.authorARAUJO, ELAINE B. dept_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2021-04-06T12:56:05Z
dc.date.available2021-04-06T12:56:05Z
dc.date.issued2021pt_BR
dc.description.abstractIn the present work, the radioimmunoconjugates 111In-DTPA-trastuzumab and 177Lu-DOTA-trastuzumab were evaluated regarding the influence of the chelating agents on the physical–chemical parameters and human epidermal growth factor receptor 2 (HER2) tumor cell binding. Data showed that both chelating agents, at predetermined molar ratios (antibody:chelator 􀀀 1:10 and 1:20), did not influence the immunoconjugates integrity, the radiolabeling process and the radiolabeled antibodies stability. However, differences were observed in the lipophilic feature between DOTA and DTPA radioimmunoconjugates and in the specific binding to SK-BR-3 tumor cells (HER2 positive). Therefore, this study showed the importance of assessing the influence of chelating agents and their molar ratios in the development process of radioimmunoconjugates.pt_BR
dc.format.extent1-9pt_BR
dc.identifier.citationMIRANDA, ANA C.C.; DURANTE, ANA C.R.; FUSCALDI, LEONARDO L.; BARBEZAN, ANGELICA B.; LIMA, CILENE R. de; PERINI, EFRAIN; ARAUJO, ELAINE B. de. Anti-HER2 monoclonal antibody based-radioimmunoconjugates: assessment of the chelating agent influence. <b>Bioorganic & Medicinal Chemistry</b>, v. 33, p. 1-9, 2021. DOI: <a href="https://dx.doi.org/10.1016/j.bmc.2021.115996">10.1016/j.bmc.2021.115996</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31971.
dc.identifier.doi10.1016/j.bmc.2021.115996pt_BR
dc.identifier.issn0968-0896pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.percentilfi49.69pt_BR
dc.identifier.percentilfiCiteScore68.57
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31971
dc.identifier.vol33pt_BR
dc.relation.ispartofBioorganic & Medicinal Chemistrypt_BR
dc.rightsclosedAccesspt_BR
dc.subjecttumor cells
dc.subjectneoplasms
dc.subjectdrugs
dc.subjecttherapeutic uses
dc.subjectradioimmunotherapy
dc.subjectchelating agents
dc.subjectradioisotopes
dc.titleAnti-HER2 monoclonal antibody based-radioimmunoconjugatespt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorANGELICA BUENO BARBEZAN
ipen.autorEFRAIN ARAUJO PERINI
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorANA CLAUDIA CAMARGO
ipen.codigoautor6417
ipen.codigoautor9691
ipen.codigoautor664
ipen.codigoautor2704
ipen.contributor.ipenauthorANGELICA BUENO BARBEZAN
ipen.contributor.ipenauthorEFRAIN ARAUJO PERINI
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorANA CLAUDIA CAMARGO
ipen.date.recebimento21-04
ipen.identifier.fi3.461pt_BR
ipen.identifier.fiCiteScore6.5
ipen.identifier.ipendoc27742pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi25.00 - 49.99
ipen.subtituloassessment of the chelating agent influencept_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication27082032-b0c8-462c-8d6c-767873119adf
relation.isAuthorOfPublication307728ba-f5be-4432-be6f-6ae9c8d445b5
relation.isAuthorOfPublicationca74886d-6974-47a8-9308-c4cc39bb6e35
relation.isAuthorOfPublication3ddf733d-da10-423a-be76-e553f76a6e49
relation.isAuthorOfPublication.latestForDiscovery3ddf733d-da10-423a-be76-e553f76a6e49
sigepi.autor.atividadeARAUJO, ELAINE B. de:664:110:Npt_BR
sigepi.autor.atividadePERINI, EFRAIN:9691:110:Npt_BR
sigepi.autor.atividadeBARBEZAN, ANGELICA B.:6417:230:Npt_BR
sigepi.autor.atividadeMIRANDA, ANA C.C.:2704:110:Spt_BR
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