Radioimmunotheranostic pair based on the anti-HER2 monoclonal antibody

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dc.contributor.authorMIRANDA, ANA C.C.pt_BR
dc.contributor.authorSANTOS, SOFIA N. dospt_BR
dc.contributor.authorFUSCALDI, LEONARDO L.pt_BR
dc.contributor.authorBALIEIRO, LUIZA M.pt_BR
dc.contributor.authorBELLINI, MARIA H.pt_BR
dc.contributor.authorGUIMARAES, MARIA I.C.C.pt_BR
dc.contributor.authorARAUJO, ELAINE B. dept_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2021-10-27T14:16:14Z
dc.date.available2021-10-27T14:16:14Z
dc.date.issued2021pt_BR
dc.description.abstractThe oncogene HER2 is an important molecular target in oncology because it is associated with aggressive disease and the worst prognosis. The development of non-invasive imaging techniques and target therapies using monoclonal antibodies is a rapidly developing field. Thus, this work proposes the study of the radioimmunotheranostic pair, [111In]In-DTPA-trastuzumab and [177Lu]Lu-DOTA-trastuzumab, evaluating the influence of the chelating agents and radionuclides on the biological properties of the radioimmunoconjugates (RICs). The trastuzumab was immunoconjugated with the chelators DTPA and DOTA and radiolabeled with [111In]InCl3 and [177Lu]LuCl3, respectively. The stability of the RICs was evaluated in serum, and the immunoreactive and internalization fractions were determined in SK-BR-3 breast cancer cells. The in vivo pharmacokinetics and dosimetry quantification and the ex vivo biodistribution were performed in normal and SK-BR-3 tumor-bearing mice. The data showed that there was no influence of the chelating agents and radionuclides on the immunoreactive and internalization fractions of RICs. In contrast, they influenced the stability of RICs in serum, as well as the pharmacokinetics, dosimetry and biodistribution profiles. Therefore, the results showed that the nature of the chelating agent and radionuclide could influence the biological properties of the radioimmunotheranostic pair.pt_BR
dc.format.extent1-16pt_BR
dc.identifier.citationMIRANDA, ANA C.C.; SANTOS, SOFIA N. dos; FUSCALDI, LEONARDO L.; BALIEIRO, LUIZA M.; BELLINI, MARIA H.; GUIMARAES, MARIA I.C.C.; ARAUJO, ELAINE B. de. Radioimmunotheranostic pair based on the anti-HER2 monoclonal antibody: influence of chelating agents and radionuclides on biological properties. <b>Pharmaceutics</b>, v. 13, n. 7, p. 1-16, 2021. DOI: <a href="https://dx.doi.org/10.3390/pharmaceutics13070971">10.3390/pharmaceutics13070971</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/32304.
dc.identifier.doi10.3390/pharmaceutics13070971pt_BR
dc.identifier.fasciculo7pt_BR
dc.identifier.issn1999-4923pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.orcidhttps://orcid.org/0000-0003-2852-6189
dc.identifier.percentilfi86.20pt_BR
dc.identifier.percentilfiCiteScore74.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/32304
dc.identifier.vol13pt_BR
dc.relation.ispartofPharmaceuticspt_BR
dc.rightsopenAccesspt_BR
dc.subjectoncogenes
dc.subjectmammary glands
dc.subjectneoplasms
dc.subjectmonoclonal antibodies
dc.subjecttheranostics
dc.titleRadioimmunotheranostic pair based on the anti-HER2 monoclonal antibodypt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorSOFIA NASCIMENTO DOS SANTOS
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorMARIA HELENA BELLINI MARUMO
ipen.autorLUIZA MASCARENHAS BALIEIRO
ipen.autorANA CLAUDIA CAMARGO
ipen.codigoautor14464
ipen.codigoautor664
ipen.codigoautor1242
ipen.codigoautor11603
ipen.codigoautor2704
ipen.contributor.ipenauthorSOFIA NASCIMENTO DOS SANTOS
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorMARIA HELENA BELLINI MARUMO
ipen.contributor.ipenauthorLUIZA MASCARENHAS BALIEIRO
ipen.contributor.ipenauthorANA CLAUDIA CAMARGO
ipen.date.recebimento21-10
ipen.identifier.fi6.525pt_BR
ipen.identifier.fiCiteScore6.0
ipen.identifier.ipendoc28072pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi6.000 ou mais
ipen.range.percentilfi75.00 - 100.00
ipen.subtituloinfluence of chelating agents and radionuclides on biological propertiespt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationab78881a-78eb-42be-a463-aaf80e70de3d
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relation.isAuthorOfPublication6a450cbf-91b1-4386-b4a8-7304afac99cc
relation.isAuthorOfPublication405bc37a-8db8-4e93-9cb7-7069e83c524f
relation.isAuthorOfPublication3ddf733d-da10-423a-be76-e553f76a6e49
relation.isAuthorOfPublication.latestForDiscovery3ddf733d-da10-423a-be76-e553f76a6e49
sigepi.autor.atividadeARAUJO, ELAINE B. de:664:110:Npt_BR
sigepi.autor.atividadeBELLINI, MARIA H.:1242:810:Npt_BR
sigepi.autor.atividadeBALIEIRO, LUIZA M.:11603:110:Npt_BR
sigepi.autor.atividadeSANTOS, SOFIA N. dos:14464:110:Npt_BR
sigepi.autor.atividadeMIRANDA, ANA C.C.:2704:110:Spt_BR
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