Innovative burn treatment using tilapia skin as a xenograft

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dc.contributor.authorLIMA JUNIOR, EDMAR M.pt_BR
dc.contributor.authorMORAES FILHO, MANOEL O. dept_BR
dc.contributor.authorCOSTA, BRUNO A.pt_BR
dc.contributor.authorROHLEDER, ANDREA V.P.pt_BR
dc.contributor.authorROCHA, MARINA B.S.pt_BR
dc.contributor.authorFECHINE, FRANCISCO V.pt_BR
dc.contributor.authorFORTE, ANTONIO J.pt_BR
dc.contributor.authorALVES, ANA P.N.N.pt_BR
dc.contributor.authorSILVA JUNIOR, FRANCISCO R.pt_BR
dc.contributor.authorMARTINS, CAMILA B.pt_BR
dc.contributor.authorMATHOR, MONICA B.pt_BR
dc.contributor.authorMORAES, MARIA E.A. dept_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2021-02-25T13:35:16Z
dc.date.available2021-02-25T13:35:16Z
dc.date.issued2020pt_BR
dc.description.abstractSkin substitutes are considered a useful alternative for occlusive dressings in the treatment of superficial burns as they reduce the frequency of dressing replacement. This phase II randomized controlled trial aimed to evaluate the efficacy of Nile tilapia (Oreochromis niloticus) skin as an occlusive xenograft dressing for the treatment of burn wounds in humans. In order to assess the use of tilapia skin, the following variables were evaluated: number of days for wound healing, the number of times the occlusive dressing was changed, use of anesthetics or analgesics, pain assessment using the Visual Analogue Scale, and evaluation of burn improvement on the day of dressing removal. In total, 62 participants completed the study. It was found that in participants treated with tilapia skin, complete reepithelialization occurred in significantly fewer days; reported pain intensity was lower (study arms B and C), the amount of anesthetics/analgesics required was lower (study arms B and C), and the necessity of dressing changes was significantly reduced in comparison with volunteers treated with silver sulfadiazine. In our study, the tilapia skin xenograft showed good efficacy as an occlusive biological dressing for burn wound treatment in humans.pt_BR
dc.format.extent585-592pt_BR
dc.identifier.citationLIMA JUNIOR, EDMAR M.; MORAES FILHO, MANOEL O. de; COSTA, BRUNO A.; ROHLEDER, ANDREA V.P.; ROCHA, MARINA B.S.; FECHINE, FRANCISCO V.; FORTE, ANTONIO J.; ALVES, ANA P.N.N.; SILVA JUNIOR, FRANCISCO R.; MARTINS, CAMILA B.; MATHOR, MONICA B.; MORAES, MARIA E.A. de. Innovative burn treatment using tilapia skin as a xenograft: a phase II randomized controlled trial. <b>Journal of Burn Care & Research</b>, v. 41, n. 3, p. 585-592, 2020. DOI: <a href="https://dx.doi.org/10.1093/jbcr/irz205">10.1093/jbcr/irz205</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31824.
dc.identifier.doi10.1093/jbcr/irz205pt_BR
dc.identifier.fasciculo3pt_BR
dc.identifier.issn1559-047Xpt_BR
dc.identifier.orcid0000-0002-7294-9106pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-7294-9106
dc.identifier.percentilfi24.56pt_BR
dc.identifier.percentilfiCiteScore75.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31824
dc.identifier.vol41pt_BR
dc.relation.ispartofJournal of Burn Care & Researchpt_BR
dc.rightsopenAccesspt_BR
dc.subjecttherapy
dc.subjectskin
dc.subjectwounds
dc.subjectanimal tissues
dc.subjectfishes
dc.subjectgrafts
dc.subjectsilver
dc.subjectsulfadiazine
dc.titleInnovative burn treatment using tilapia skin as a xenograftpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMONICA BEATRIZ MATHOR
ipen.codigoautor209
ipen.contributor.ipenauthorMONICA BEATRIZ MATHOR
ipen.date.recebimento21-02
ipen.identifier.fi1.845pt_BR
ipen.identifier.fiCiteScore2.8
ipen.identifier.ipendoc27597pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi0.00 - 24.99
ipen.subtituloa phase II randomized controlled trialpt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication742b424f-9dfb-4e4a-993b-000052bb1313
relation.isAuthorOfPublication.latestForDiscovery742b424f-9dfb-4e4a-993b-000052bb1313
sigepi.autor.atividadeMATHOR, MONICA B.:209:220:Npt_BR
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