A comparison between two populations of mesenchymal stem cells that can improve the osteogenesis imperfecta mouse phenotype

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dc.contributor.authorGOMES, ALISSANDRA de M.pt_BR
dc.contributor.authorJESUS, GUSTAVO P.P. dept_BR
dc.contributor.authorZACARIAS, ENIO A.pt_BR
dc.contributor.authorYOSIDAKI, VANESSA L.pt_BR
dc.contributor.authorLIMA, DARLE B. dept_BR
dc.contributor.authorCOSTA, RAFAEL S.pt_BR
dc.contributor.authorRANGEL, ERIKA B.pt_BR
dc.contributor.authorSOUSA, POLIANA E.S.pt_BR
dc.contributor.authorSILVA, CHRISTIAN S.pt_BR
dc.contributor.authorBARTOLINI, PAOLOpt_BR
dc.contributor.authorPERONI, CIBELE N.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoCONGRESS OF THE BRAZILIAN SOCIETY FOR CELL BIOLOGY, 20thpt_BR
dc.date.accessioned2022-02-01T18:19:23Z
dc.date.available2022-02-01T18:19:23Z
dc.date.eventoJanuary 27-29, 2021pt_BR
dc.description.abstractOsteogenesis imperfecta (OI) is an inherited disease characterized by fragility, deformity and low bone density, besides other clinical manifestations. Type-I OI is the mildest and most common form of the disease, caused by a mutation in the COL1A1 gene and resulting in half normal-collagen production. Our purpose was to compare mesenchymal stem cells from bone marrow (BM-MSCs) with those from adipose tissue (AD-MSCs), both used for improving heterozygous oim mice phenotype, similar to human type-I OI. Mice were irradiated and cells injected into femoral condyles, bone mineral density (BMD) and femoral length were measured by X-ray, at the beginning and end of the assay. Femurs and quadriceps allowed bone fragility evaluation by biomechanical test and collagen Col1a1 and Col1a2 quantification via ELISA. BMD showed no significant difference between the groups, while femur length variation was higher in the BM-MSCs group, compared with the control (P=0.0301). Fragility was improved with AD-MSCs when flexion extension to fracture (P=0.0028) and time to fracture (P=0.0032) were evaluated. There was no significant difference in the maximum load supported by femurs until fracture. An increase in Col1a1 concentration with BM-MSCs in comparison with AD-MSCs (P=0.0281) was obtained. Although no significant difference in Col1a2 concentration was observed between the groups, a higher expression level was obtained with AD-MSCs. We can thus conclude that AD-MSCs were more efficient than BM-MSCs for improving bone quality in type-I OI.pt_BR
dc.format.extent249-250pt_BR
dc.identifier.citationGOMES, ALISSANDRA de M.; JESUS, GUSTAVO P.P. de; ZACARIAS, ENIO A.; YOSIDAKI, VANESSA L.; LIMA, DARLE B. de; COSTA, RAFAEL S.; RANGEL, ERIKA B.; SOUSA, POLIANA E.S.; SILVA, CHRISTIAN S.; BARTOLINI, PAOLO; PERONI, CIBELE N. A comparison between two populations of mesenchymal stem cells that can improve the osteogenesis imperfecta mouse phenotype. In: CONGRESS OF THE BRAZILIAN SOCIETY FOR CELL BIOLOGY, 20th, January 27-29, 2021, Online. <b>Abstract...</b> São Paulo, SP: Sociedade Brasileira de Biologia Celular, 2021. p. 249-250. Disponível em: http://repositorio.ipen.br/handle/123456789/32682.
dc.identifier.orcidhttps://orcid.org/0000-0001-8194-5230
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/32682
dc.localSão Paulo, SPpt_BR
dc.local.eventoOnlinept_BR
dc.publisherSociedade Brasileira de Biologia Celularpt_BR
dc.rightsopenAccesspt_BR
dc.titleA comparison between two populations of mesenchymal stem cells that can improve the osteogenesis imperfecta mouse phenotypept_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorGUSTAVO PROTASIO PACHECO DE JESUS
ipen.autorVANESSA DE LUNA YOSIDAKI
ipen.autorRAFAEL DA SILVA COSTA
ipen.autorCIBELE NUNES PERONI
ipen.autorPAOLO BARTOLINI
ipen.autorDARLE BERNARDO DE LIMA
ipen.autorENIO APARECIDO ZACARIAS
ipen.autorALISSANDRA DE MOURA GOMES
ipen.codigoautor14229
ipen.codigoautor14922
ipen.codigoautor15116
ipen.codigoautor947
ipen.codigoautor1503
ipen.codigoautor15072
ipen.codigoautor14288
ipen.codigoautor14488
ipen.contributor.ipenauthorGUSTAVO PROTASIO PACHECO DE JESUS
ipen.contributor.ipenauthorVANESSA DE LUNA YOSIDAKI
ipen.contributor.ipenauthorRAFAEL DA SILVA COSTA
ipen.contributor.ipenauthorCIBELE NUNES PERONI
ipen.contributor.ipenauthorPAOLO BARTOLINI
ipen.contributor.ipenauthorDARLE BERNARDO DE LIMA
ipen.contributor.ipenauthorENIO APARECIDO ZACARIAS
ipen.contributor.ipenauthorALISSANDRA DE MOURA GOMES
ipen.date.recebimento22-02
ipen.event.datapadronizada2021pt_BR
ipen.identifier.ipendoc28450pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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sigepi.autor.atividadePERONI, CIBELE N.:947:810:Npt_BR
sigepi.autor.atividadeBARTOLINI, PAOLO:1503:810:Npt_BR
sigepi.autor.atividadeCOSTA, RAFAEL S.:15116:810:Npt_BR
sigepi.autor.atividadeLIMA, DARLE B. de:15072:810:Npt_BR
sigepi.autor.atividadeYOSIDAKI, VANESSA L.:14922:810:Npt_BR
sigepi.autor.atividadeZACARIAS, ENIO A.:14288:810:Npt_BR
sigepi.autor.atividadeJESUS, GUSTAVO P.P. de:14229:810:Npt_BR
sigepi.autor.atividadeGOMES, ALISSANDRA de M.:14488:810:Spt_BR
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