Apoptosis through Bcl-2/Bax and cleaved caspase Up-regulation in melanoma treated by boron neutron capture therapy

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dc.contributor.authorFAIAO FLORES, FERNANDApt_BR
dc.contributor.authorCOELHO, PAULO R.P.pt_BR
dc.contributor.authorARRUDA NETO, JOAO D.T.pt_BR
dc.contributor.authorMARIA ENGLER, SILVYA S.pt_BR
dc.contributor.authorTIAGO, MANOELApt_BR
dc.contributor.authorCAPELOZZI, VERA L.pt_BR
dc.contributor.authorGIOGI, RICARDO R.pt_BR
dc.contributor.authorMARIA, DURVANEI A.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-07-31T11:35:55Zpt_BR
dc.date.accessioned2014-07-31T11:53:06Z
dc.date.available2014-07-31T11:35:55Zpt_BR
dc.date.available2014-07-31T11:53:06Z
dc.date.issued2013pt_BR
dc.description.abstractBoron neutron capture therapy (BNCT) is a binary treatment involving selective accumulation of boron carriers in a tumor followed by irradiation with a thermal or epithermal neutron beam. The neutron capture reaction with a boron-10 nucleus yields high linear energy transfer (LET) particles, alpha and 7 Li, with a range of 5 to 9 mm. These particles can only travel very short distances and release their damaging energy directly into the cells containing the boron compound. We aimed to evaluate proliferation, apoptosis and extracellular matrix (ECM) modifications of B16F10 melanoma and normal human melanocytes after BNCT. The amounts of soluble collagen and Hsp47, indicating collagen synthesis in the ECM, as well as the cellular markers of apoptosis, were investigated. BNCT decreased proliferation, altered the ECM by decreasing collagen synthesis and induced apoptosis by regulating Bcl-2/Bax in melanoma. Additionally, BNCT also increased the levels of TNF receptor and the cleaved caspases 3, 7, 8 and 9 in melanoma. These results suggest that multiple pathways related to cell death and cell cycle arrest are involved in the treatment of melanoma by BNCT.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP:08/56397-8; 08/58817-4pt_BR
dc.identifier.citationFAIAO FLORES, FERNANDA; COELHO, PAULO R.P.; ARRUDA NETO, JOAO D.T.; MARIA ENGLER, SILVYA S.; TIAGO, MANOELA; CAPELOZZI, VERA L.; GIOGI, RICARDO R.; MARIA, DURVANEI A. Apoptosis through Bcl-2/Bax and cleaved caspase Up-regulation in melanoma treated by boron neutron capture therapy. <b>PLoS ONE</b>, v. 8, n. 3, 2013. DOI: <a href="https://dx.doi.org/10.1371/journal.pone.0059639">10.1371/journal.pone.0059639</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/8466.
dc.identifier.doi10.1371/journal.pone.0059639
dc.identifier.fasciculo3pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/8466pt_BR
dc.identifier.vol8pt_BR
dc.relation.ispartofPLoS ONEpt_BR
dc.rightsopenAccessen
dc.subjectboron 10pt_BR
dc.subjectmelanomaspt_BR
dc.subjectapoptosispt_BR
dc.subjectneutron capture therapypt_BR
dc.subjectneutron fluxpt_BR
dc.subjectphenylalaninept_BR
dc.subjectradiation effectspt_BR
dc.titleApoptosis through Bcl-2/Bax and cleaved caspase Up-regulation in melanoma treated by boron neutron capture therapypt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorS. S. MARIA-ENGLER
ipen.autorDURVANEI AUGUSTO MARIA
ipen.autorPAULO ROGERIO PINTO COELHO
ipen.autorFERNANDA FAIÂO FLORES
ipen.codigoautor11061
ipen.codigoautor12160
ipen.codigoautor1366
ipen.codigoautor10662
ipen.contributor.ipenauthorS. S. MARIA-ENGLER
ipen.contributor.ipenauthorDURVANEI AUGUSTO MARIA
ipen.contributor.ipenauthorPAULO ROGERIO PINTO COELHO
ipen.contributor.ipenauthorFERNANDA FAIÂO FLORES
ipen.date.recebimento13-11pt_BR
ipen.identifier.fi3.534pt_BR
ipen.identifier.ipendoc19223pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi3.000 - 4.499
ipen.type.genreArtigo
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sigepi.autor.atividadeFAIAO FLORES, FERNANDA:10662:420:Spt_BR
sigepi.autor.atividadeCOELHO, PAULO R.P.:1366:420:Npt_BR
sigepi.autor.atividadeARRUDA NETO, JOAO D.T.:-1:-1:Npt_BR
sigepi.autor.atividadept_BR
sigepi.autor.atividadeMARIA ENGLER, SILVYA S.:11061:-1:Npt_BR
sigepi.autor.atividadept_BR
sigepi.autor.atividadeTIAGO, MANOELA:-1:-1:Npt_BR
sigepi.autor.atividadeCAPELOZZI, VERA L.:-1:-1:Npt_BR
sigepi.autor.atividadept_BR
sigepi.autor.atividadept_BR
sigepi.autor.atividadeGIOGI, RICARDO R.:-1:-1:Npt_BR
sigepi.autor.atividadeMARIA, DURVANEI A.:12160:-1:Npt_BR
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