Influence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels

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dc.contributor.authorMARIANO, KELLI C.F.pt_BR
dc.contributor.authorNASCIMENTO, MONICA H.M. dopt_BR
dc.contributor.authorQUEROBINO, SAMYR M.pt_BR
dc.contributor.authorCAMPOS, ESTEFANIA V.R.pt_BR
dc.contributor.authorOLIVEIRA, JHONES L. dept_BR
dc.contributor.authorYOKAICHIYA, FABIANOpt_BR
dc.contributor.authorFRANCO, MARGARETH K.K.D.pt_BR
dc.contributor.authorALBERTO-SILVA, CARLOSpt_BR
dc.contributor.authorPAULA, ENEIDA dept_BR
dc.contributor.authorLOMBELLO, CHRISTIANE B.pt_BR
dc.contributor.authorLIMA, RENATA dept_BR
dc.contributor.authorFRACETO, LEONARDO F.pt_BR
dc.contributor.authorARAUJO, DANIELE R. dept_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-04-07T12:11:07Z
dc.date.available2020-04-07T12:11:07Z
dc.date.issued2020pt_BR
dc.description.abstractChitosan-tripolyphosphate (CS-TPP) nanoparticles containing naproxen (NPX) were dispersed in poloxamer (PL) as unique (PL407) or binary (PL407-PL403) systems. Nanoparticles presented diameter of 250nm and zeta potential of 35mV with drug loading and encapsulation efficiency of 98.4 ± 0.3% and 36.9 ± 0.12%, respectively. NPX-CS-TPP shifted the sol-gel transition and micellization temperatures. PL407-PL403 systems presented G0 >G00 compared to PL407. SAXS patterns revealed transitions from lamellar to hexagonal phase organizations with low drug release rates, in the presence of CS-TPP nanoparticles. NPX-CS-TPP-PL407 induced lower cytotoxicity compared to PL407-PL403 in fibroblasts and osteoblasts, making them promising systems for intra-articular delivery.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipIDFAPESP: 14/26200-9; 14/14457-5; 14/12653-1pt_BR
dc.description.sponsorshipIDCNPq: 309207/2016-9; 402838/2016-5pt_BR
dc.format.extent592-603pt_BR
dc.identifier.citationMARIANO, KELLI C.F.; NASCIMENTO, MONICA H.M. do; QUEROBINO, SAMYR M.; CAMPOS, ESTEFANIA V.R.; OLIVEIRA, JHONES L. de; YOKAICHIYA, FABIANO; FRANCO, MARGARETH K.K.D.; ALBERTO-SILVA, CARLOS; PAULA, ENEIDA de; LOMBELLO, CHRISTIANE B.; LIMA, RENATA de; FRACETO, LEONARDO F.; ARAUJO, DANIELE R. de. Influence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels: structural organization, drug release mechanisms and cytotoxicity. <b>International Journal of Polymeric Materials and Polymeric Biomaterials</b>, v. 69, n. 9, p. 592-603, 2020. DOI: <a href="https://dx.doi.org/10.1080/00914037.2019.1596909">10.1080/00914037.2019.1596909</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31100.
dc.identifier.doi10.1080/00914037.2019.1596909pt_BR
dc.identifier.fasciculo9pt_BR
dc.identifier.issn0091-4037pt_BR
dc.identifier.percentilfi37.16pt_BR
dc.identifier.percentilfiCiteScore67.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31100
dc.identifier.vol69pt_BR
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialspt_BR
dc.rightsopenAccesspt_BR
dc.subjectpolysaccharides
dc.subjectchitin
dc.subjectnanoparticles
dc.subjectantipyretics
dc.subjectdrugs
dc.subjectviability
dc.subjectanimal cells
dc.subjectsensitivity
dc.subjecttemperature dependence
dc.subjecthydrogels
dc.titleInfluence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogelspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMARGARETH KAZUYO KOBAYASHI DIAS FRANCO
ipen.codigoautor9803
ipen.contributor.ipenauthorMARGARETH KAZUYO KOBAYASHI DIAS FRANCO
ipen.date.recebimento20-04
ipen.identifier.fi2.604pt_BR
ipen.identifier.fiCiteScore4.2
ipen.identifier.ipendoc25785pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi25.00 - 49.99
ipen.subtitulostructural organization, drug release mechanisms and cytotoxicitypt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationea01b86e-8435-405e-874c-d0b68fb2b549
relation.isAuthorOfPublication.latestForDiscoveryea01b86e-8435-405e-874c-d0b68fb2b549
sigepi.autor.atividadeFRANCO, MARGARETH K.K.D.:9803:1120:Npt_BR
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