Tryptophan silver nanoparticles synthesized by photoreduction method

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dc.contributor.authorCOURROL, DANIELLA dos S.pt_BR
dc.contributor.authorLOPES, CARLA R.B.pt_BR
dc.contributor.authorPEREIRA, CAMILA B.P.pt_BR
dc.contributor.authorFRANZOLIN, MARCIA R.pt_BR
dc.contributor.authorSILVA, FLAVIA R. de O.pt_BR
dc.contributor.authorCOURROL, LILIA C.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2019-08-08T18:38:12Z
dc.date.available2019-08-08T18:38:12Z
dc.date.issued2019pt_BR
dc.description.abstractThe high rates of antibiotics use in hospitals have resulted in a condition where multidrug-resistant pathogens have become a severe threat to the human health worldwide. Therefore, there is an increasing necessity to identify new antimicrobial agents that can inhibit the multidrugresistant bacteria and biofilm formation. In this study, antibacterial and anti-biofilm activities of tryptophan silver nanoparticles (TrpAgNP) were investigated. The TrpAgNPs were synthesized by photoreduction method, and the influence of irradiation time and concentration of reagents were analyzed. The nanoparticles were characterized by transmission electron microscopy, Zeta Potential and (UV)-absorption spectra. The antibacterial activity of TrpAgNPs was tested for antibiotic-resistant and susceptible pathogens, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Citrobacter freundii, Klebsiella pneumoniae, Salmonella typhimurium, and Pseudomonas aeruginosa, evaluating the influence of photoreduction parameters in bactericidal effect. The results have shown that TrpAgNPs solutions with lower tryptophan/silver nitrate (AgNO3) ratio and higher AgNO3 concentration have higher bactericidal action against bacteria with inhibition of ~100% in almost all studied bacterial strains. The antimicrobial activity of TrpAgNPs within biofilms generated under static conditions of antibiotic-resistant and susceptible strains of S. aureus, S. epidermidis, E. coli, K. pneumoniae, C. freundii, and P. aeruginosa was also investigated. The results showed that TrpAgNPs have an inhibitory effect against biofilm formation, exceeding 50% in the case of Gram-negative bacteria (E. coli, K. pneumoniae, C. freundii, and P. aeruginosa—54.8% to 98.8%). For Gram-positive species, an inhibition of biofilm formation of 68.7% to 72.2 % was observed for S. aureus and 20.0% to 40.2% for S. epidermidis.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP :14/06960-9pt_BR
dc.format.extent1-8pt_BR
dc.identifier.citationCOURROL, DANIELLA dos S.; LOPES, CARLA R.B.; PEREIRA, CAMILA B.P.; FRANZOLIN, MARCIA R.; SILVA, FLAVIA R. de O.; COURROL, LILIA C. Tryptophan silver nanoparticles synthesized by photoreduction method: characterization and determination of bactericidal and anti-biofilm activities on resistant and susceptible bacteria. <b>International Journal of Tryptophan Research</b>, v. 12, p. 1-8, 2019. DOI: <a href="https://dx.doi.org/10.1177/1178646919831677">10.1177/1178646919831677</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/30045.
dc.identifier.doi10.1177/1178646919831677pt_BR
dc.identifier.issn1178-6469pt_BR
dc.identifier.percentilfiSem Percentilpt_BR
dc.identifier.percentilfiCiteScore84.50
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/30045
dc.identifier.vol12pt_BR
dc.relation.ispartofInternational Journal of Tryptophan Researchpt_BR
dc.rightsopenAccesspt_BR
dc.subjectantimicrobial agents
dc.subjectsilver
dc.subjectantibiotics
dc.subjecttryptophan
dc.subjectnanoparticles
dc.subjectirradiation
dc.subjectphotosynthetic bacteria
dc.subjectphotochemical reactions
dc.titleTryptophan silver nanoparticles synthesized by photoreduction methodpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorFLAVIA RODRIGUES DE OLIVEIRA SILVA
ipen.codigoautor5910
ipen.contributor.ipenauthorFLAVIA RODRIGUES DE OLIVEIRA SILVA
ipen.date.recebimento19-08
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.fiCiteScore8.1
ipen.identifier.ipendoc25838pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.subtitulocharacterization and determination of bactericidal and anti-biofilm activities on resistant and susceptible bacteriapt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationb1aa6134-5ebc-46f0-ada3-605eaec3a986
relation.isAuthorOfPublication.latestForDiscoveryb1aa6134-5ebc-46f0-ada3-605eaec3a986
sigepi.autor.atividadeSILVA, FLAVIA R. de O.:5910:820:Npt_BR
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