Nanocomposite polymer clay to support the release of drug

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dc.contributor.authorOLIVEIRA, MARIA J.A.
dc.contributor.authorLUGAO, ADEMAR B.
dc.contributor.authorPARRA, DUCLERC F.
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-02-19T16:48:16Z
dc.date.available2018-02-19T16:48:16Z
dc.date.issued2017pt_BR
dc.description.abstractIt is estimated that there are about 300,00 products named biomaterials that are used in the area of Health. Although they are widely used they have yet to be optimized for therapeutic use. Hence, the objective of this work was to develop nanocomposites hydrogels with poly (vinyl alcohol) (PVAl), glucantime, chitosan and synthetic clay Laponite RD, processed by gamma irradiation. To compare the behavior of drug release two systems were compared, PVAl / chitosan / clay and PVAl / clay. The morphology of the nanocomposites hydrogel was understood by using characterization techniques: X-ray diffraction, scanning electron microscopy (SEM) and atomic force microscopy (AFM) and gel fraction. The release kinetics was analyzed at 37 °C for period of 48 hours. It was observed that the slower release of the drug occurs in the delivery system composed by PVAl / chitosan / clay with correlation of the crosslink type formed by chitosan.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 09/50926-1pt_BR
dc.format.extent335-340pt_BR
dc.identifier.citationOLIVEIRA, MARIA J.A.; LUGAO, ADEMAR B.; PARRA, DUCLERC F. Nanocomposite polymer clay to support the release of drug. <b>Materials Science Forum</b>, v. 899, p. 335-340, 2017. DOI: <a href="https://dx.doi.org/10.4028/www.scientific.net/MSF.899.335">10.4028/www.scientific.net/MSF.899.335</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28495.
dc.identifier.doi10.4028/www.scientific.net/MSF.899.335pt_BR
dc.identifier.issn1662-9752pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7626-880X
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.percentilfiSem Percentilen
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28495
dc.identifier.vol899pt_BR
dc.relation.ispartofMaterials Science Forumpt_BR
dc.rightsopenAccesspt_BR
dc.subjectnanocomposites
dc.subjectpolymers
dc.subjectclays
dc.subjecthydrogels
dc.subjectpolysaccharides
dc.subjectdrugs
dc.titleNanocomposite polymer clay to support the release of drugpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorDUCLERC FERNANDES PARRA
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorMARIA JOSE ALVES DE OLIVEIRA
ipen.codigoautor562
ipen.codigoautor339
ipen.codigoautor3310
ipen.contributor.ipenauthorDUCLERC FERNANDES PARRA
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorMARIA JOSE ALVES DE OLIVEIRA
ipen.date.recebimento18-02pt_BR
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.ipendoc24359pt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication67996d86-0a59-4ba2-8d38-facaa14e26c3
relation.isAuthorOfPublication99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
relation.isAuthorOfPublicationdb19966e-6f74-43fc-84b1-c24c1d826e0c
relation.isAuthorOfPublication.latestForDiscoverydb19966e-6f74-43fc-84b1-c24c1d826e0c
sigepi.autor.atividadeOLIVEIRA, MARIA J.A.:3310:740:Spt_BR
sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Npt_BR
sigepi.autor.atividadePARRA, DUCLERC F.:562:740:Npt_BR
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