Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines

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dc.contributor.authorKLINGBEIL, MARIA F.G.pt_BR
dc.contributor.authorXAVIER, FLAVIA C.A.pt_BR
dc.contributor.authorSARDINHA, LUIZ R.pt_BR
dc.contributor.authorSEVERINO, PATRICIApt_BR
dc.contributor.authorMATHOR, MONICA B.pt_BR
dc.contributor.authorRODRIGUES, RODRIGO V.pt_BR
dc.contributor.authorPINTO JUNIOR, DECIO S.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-07-15T13:33:26Zpt_BR
dc.date.accessioned2014-07-30T11:48:33Z
dc.date.available2014-07-15T13:33:26Zpt_BR
dc.date.available2014-07-30T11:48:33Z
dc.date.issued2013pt_BR
dc.description.abstractHead and neck squamous cell carcinoma is a complex disease with several etiologic factors and different molecular changes that may trigger certain events; it is also globally one of the most common malignancies in this topography. Extracts from Viscum album L. (VA) (mistletoe) have been used as adjuvant therapies with promising results in several types of cancer, mainly in European countries. In vitro studies have demonstrated that various types of VA may have cytotoxicity in carcinoma cells, activating the apoptotic cascade or leading cells to necrosis. This study aimed to verify the effects of three types of VA extracts (Iscador Qu Spezial, Iscador P and Iscador M) in squamous cell carcinoma of the tongue cell lines SCC9 and SCC25, not previously studied. A concentration of 0.3 mg/ml (IC50) of the drugs induced apoptosis, affecting gene expression and protein levels of AKT, PTEN and CYCLIN D1. It was concluded that VA extracts have a cytotoxic effect on SCC9 and SCC25 cell lines, but while SCC9 cell line was more resistant to the action of the drugs, Iscador Qu Spezial and Iscador M have higher cytotoxic potential in both cell lines compared to Iscador P.
dc.format.extent2316-2322pt_BR
dc.identifier.citationKLINGBEIL, MARIA F.G.; XAVIER, FLAVIA C.A.; SARDINHA, LUIZ R.; SEVERINO, PATRICIA; MATHOR, MONICA B.; RODRIGUES, RODRIGO V.; PINTO JUNIOR, DECIO S. Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. <b>Oncology Reports</b>, v. 30, n. 5, p. 2316-2322, 2013. DOI: <a href="https://dx.doi.org/10.3892/or.2013.2732">10.3892/or.2013.2732</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/4030.
dc.identifier.doi10.3892/or.2013.2732
dc.identifier.fasciculo5pt_BR
dc.identifier.issn1021-335Xpt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-7294-9106
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/4030pt_BR
dc.identifier.vol30pt_BR
dc.relation.ispartofOncology Reportspt_BR
dc.rightsclosedAccessen
dc.subjectcytologypt_BR
dc.subjecttoxicitypt_BR
dc.subjectplantspt_BR
dc.subjectparasitic diseasespt_BR
dc.subjectlectinspt_BR
dc.subjectcarcinomaspt_BR
dc.subjectheadpt_BR
dc.subjectneckpt_BR
dc.subjectcell culturespt_BR
dc.subjecttherapypt_BR
dc.titleCytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell linespt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorFLÁVIA C. A. XAVIER
ipen.autorLUIZ R. SARDINHA
ipen.autorPATRÍCIA SEVERINO
ipen.autorRODRIGO V. RODRIGUES
ipen.autorDÉCIO DOS SANTOS PINTO JUNIOR
ipen.autorMONICA BEATRIZ MATHOR
ipen.autorMARIA FATIMA GUARIZO KLINGBEIL
ipen.codigoautor11913
ipen.codigoautor11914
ipen.codigoautor10638
ipen.codigoautor11915
ipen.codigoautor8163
ipen.codigoautor209
ipen.codigoautor3309
ipen.contributor.ipenauthorFLÁVIA C. A. XAVIER
ipen.contributor.ipenauthorLUIZ R. SARDINHA
ipen.contributor.ipenauthorPATRÍCIA SEVERINO
ipen.contributor.ipenauthorRODRIGO V. RODRIGUES
ipen.contributor.ipenauthorDÉCIO DOS SANTOS PINTO JUNIOR
ipen.contributor.ipenauthorMONICA BEATRIZ MATHOR
ipen.contributor.ipenauthorMARIA FATIMA GUARIZO KLINGBEIL
ipen.date.recebimento13-12pt_BR
ipen.identifier.fi2.191pt_BR
ipen.identifier.ipendoc19584pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi1.500 - 2.999
ipen.type.genreArtigo
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sigepi.autor.atividadeKLINGBEIL, MARIA F.G.:3309:230:Spt_BR
sigepi.autor.atividadeXAVIER, FLAVIA C.A.:11913:-1:Npt_BR
sigepi.autor.atividadeSARDINHA, LUIZ R.:11914:-1:Npt_BR
sigepi.autor.atividadeSEVERINO, PATRICIA:10638:-1:Npt_BR
sigepi.autor.atividadeMATHOR, MONICA B.:209:220:Npt_BR
sigepi.autor.atividadeRODRIGUES, RODRIGO V.:11915:-1:Npt_BR
sigepi.autor.atividadePINTO JUNIOR, DECIO S.:8163:-1:Npt_BR
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