Nanoradiopharmaceuticals for breast cancer imaging: development, characterization, and imaging in inducted animals

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dc.contributor.authorSARCINELLI, MICHELLE A.
dc.contributor.authorALBERNAZ, MARTA de S.
dc.contributor.authorSZWED, MARZENA
dc.contributor.authorISCAIFE, ALEXANDRE
dc.contributor.authorLEITE, KATIA R.M.
dc.contributor.authorJUNQUEIRA, MARA de S.
dc.contributor.authorBERNARDES, EMERSON S.
dc.contributor.authorSILVA, EMERSON O. da
dc.contributor.authorTAVARES, MARIA I.B.
dc.contributor.authorSANTOS-OLIVEIRA, RALPH
dc.coverageInternacionalpt_BR
dc.date.accessioned2016-11-10T16:18:43Z
dc.date.available2016-11-10T16:18:43Z
dc.date.issued2016pt_BR
dc.description.abstractMonoclonal antibodies as polymeric nanoparticles are quite interesting and endow this new drug category with many advantages, especially by reducing the number of adverse reactions and, in the case of radiopharmaceuticals, also reducing the amount of radiation (dose) administered to the patient. In this study, a nanoradiopharmaceutical was developed using polylactic acid (PLA)/polyvinyl alcohol (PVA)/montmorillonite (MMT)/trastuzumab nanoparticles labeled with technetium-99m (99mTc) for breast cancer imaging. In order to confirm the nanoparticle formation, atomic force microscopy and dynamic light scattering were performed. Cytotoxicity of the nanoparticle and biodistribution with 99mTc in healthy and inducted animals were also measured. The results from atomic force microscopy showed that the nanoparticles were spherical, with a size range of ~200–500 nm. The dynamic light scattering analysis demonstrated that over 90% of the nanoparticles produced had a size of 287 nm with a zeta potential of -14,6 mV. The cytotoxicity results demonstrated that the nanoparticles were capable of reaching breast cancer cells. The biodistribution data demonstrated that the PLA/PVA/MMT/trastuzumab nanoparticles labeled with 99mTc have great renal clearance and also a high uptake by the lesion, as ~45% of the PLA/PVA/MMT/trastuzumab nanoparticles injected were taken up by the lesion. The data support PLA/PVA/MMT/trastuzumab labeled with 99mTc nanoparticles as nanoradiopharmaceuticals for breast cancer imaging.pt_BR
dc.format.extent5847-5854pt_BR
dc.identifier.citationSARCINELLI, MICHELLE A.; ALBERNAZ, MARTA de S.; SZWED, MARZENA; ISCAIFE, ALEXANDRE; LEITE, KATIA R.M.; JUNQUEIRA, MARA de S.; BERNARDES, EMERSON S.; SILVA, EMERSON O. da; TAVARES, MARIA I.B.; SANTOS-OLIVEIRA, RALPH. Nanoradiopharmaceuticals for breast cancer imaging: development, characterization, and imaging in inducted animals. <b>OncoTargets and Therapy</b>, v. 9, p. 5847-5854, 2016. DOI: <a href="https://dx.doi.org/10.2147/OTT.S110787">10.2147/OTT.S110787</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/26786.
dc.identifier.doi10.2147/OTT.S110787pt_BR
dc.identifier.issn1178-6930pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0029-7313
dc.identifier.percentilfi51.72
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/26786
dc.identifier.vol9pt_BR
dc.relation.ispartofOncoTargets and Therapypt_BR
dc.rightsclosedAccesspt_BR
dc.subjectmedicine
dc.subjectneoplasms
dc.subjectradiopharmaceuticals
dc.subjectnanotechnology
dc.subjectmammary glands
dc.subjectmolecular structure
dc.subjectimage processing
dc.subjectnanostructures
dc.subjectdiagnosis
dc.subjectnuclear medicine
dc.titleNanoradiopharmaceuticals for breast cancer imaging: development, characterization, and imaging in inducted animalspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorEMERSON SOARES BERNARDES
ipen.codigoautor12099
ipen.contributor.ipenauthorEMERSON SOARES BERNARDES
ipen.date.recebimento16-11pt_BR
ipen.identifier.fi2.612pt_BR
ipen.identifier.ipendoc22655pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods3
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreArtigo
relation.isAuthorOfPublication8115c8bd-822c-4f5a-9f49-3c12570ed40a
relation.isAuthorOfPublication.latestForDiscovery8115c8bd-822c-4f5a-9f49-3c12570ed40a
sigepi.autor.atividadeBERNARDES, EMERSON S.:12099:-1:Npt_BR
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