Photodynamic inactivation of Candida ssp. on denture stomatitis. A clinical trial involving palatal mucosa and prosthesis disinfection

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dc.contributor.authorSENNA, ANDRE M. de
dc.contributor.authorVIEIRA, MARTHA M.F.
dc.contributor.authorMACHADO-DE-SENA, ROSA M.
dc.contributor.authorBERTOLIN, APARECIDO O.
dc.contributor.authorNUNEZ, SILVIA C.
dc.contributor.authorRIBEIRO, MARTHA S.
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-07-31T13:11:55Z
dc.date.available2018-07-31T13:11:55Z
dc.date.issued2018pt_BR
dc.description.abstractDenture stomatitis (DS) is the most common oral fungal infection in denture wearers. Photodynamic inactivation (PDI) has been showing to be an effective technique in vivo against fungi, including fungal infections in the oral cavity. The disinfection of both oral mucosa and denture may represent a real advantage in terms of fungus control. This clinical study was designed to explore methylene blue (MB)-mediated PDI on oral mucosa and prosthesis of patients with DS. Subjects with DS were divided into two groups. One group received treatment based on the use of oral miconazole gel 2% (MIC). The other group received treatment by PDI using MB at 450 μg/mL and a diode laser (λ = 660 nm) with 100 mW and fluence of 28 J/cm2. Clinical outcome was evaluated regarding the degree of oral mucosa erythema and microbiological reduction of Candida spp. located in both palatal mucosa and prosthesis. Our results showed that PDI was significantly more effective than MIC in ameliorating inflammation after 15 days. Following 30 days, no statistically significant differences were observed between groups. Regarding the fungal burden, although the MIC group has presented more pronounced inactivation than PDI for both mucosa and prosthesis, no statistically significant differences were detected between them. This clinical study suggests that PDI can reduce fungal load and decrease the inflammation degree in patients with Candida-associated denture stomatitis.pt_BR
dc.format.extent212-216pt_BR
dc.identifier.citationSENNA, ANDRE M. de; VIEIRA, MARTHA M.F.; MACHADO-DE-SENA, ROSA M.; BERTOLIN, APARECIDO O.; NUNEZ, SILVIA C.; RIBEIRO, MARTHA S. Photodynamic inactivation of Candida ssp. on denture stomatitis. A clinical trial involving palatal mucosa and prosthesis disinfection. <b>Photodiagnosis and Photodynamic Therapy</b>, v. 22, p. 212-216, 2018. DOI: <a href="https://dx.doi.org/10.1016/j.pdpdt.2018.04.008">10.1016/j.pdpdt.2018.04.008</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/29004.
dc.identifier.doi10.1016/j.pdpdt.2018.04.008pt_BR
dc.identifier.issn1572-1000pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4203-1134
dc.identifier.percentilfi37.61en
dc.identifier.percentilfiCiteScore60.75
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29004
dc.identifier.vol22pt_BR
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapypt_BR
dc.rightsopenAccesspt_BR
dc.subjectphotosensitivity
dc.subjectoral cavity
dc.subjectsterilization
dc.subjectdisinfectants
dc.subjectinflammation
dc.subjectmucous membranes
dc.subjectmethylene blue
dc.subjectinactivation
dc.subjectcandida
dc.titlePhotodynamic inactivation of Candida ssp. on denture stomatitis. A clinical trial involving palatal mucosa and prosthesis disinfectionpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMARTHA SIMOES RIBEIRO
ipen.autorMARTHA MARQUES FERREIRA VIEIRA
ipen.codigoautor574
ipen.codigoautor1331
ipen.contributor.ipenauthorMARTHA SIMOES RIBEIRO
ipen.contributor.ipenauthorMARTHA MARQUES FERREIRA VIEIRA
ipen.date.recebimento18-07pt_BR
ipen.identifier.fi2.589pt_BR
ipen.identifier.fiCiteScore3.7
ipen.identifier.ipendoc24792pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublication36215a53-0150-4910-91d7-9559717b62d7
relation.isAuthorOfPublication100c64f4-bb41-4730-a5c6-6784f9d3f025
relation.isAuthorOfPublication.latestForDiscovery100c64f4-bb41-4730-a5c6-6784f9d3f025
sigepi.autor.atividadeVIEIRA, MARTHA M.F.:1331:1030:Npt_BR
sigepi.autor.atividadeRIBEIRO, MARTHA S.:574:920:Npt_BR
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